基于安全多方计算和区块链技术的中医药临床数据共享方法研究:以频数分析和描述性统计为例  

Research on Secure Sharing Methods for Clinical Data of Traditional Chinese Medicine Based on Secure Multi-Party Computation and Blockchain Technology:Taking Frequency Analysis and Descriptive Statistics As Examples

作　　者：何畅 赵冉 张雯[2] 张泽丹 温宵宵 古欣怡 庄荟瑛 王斌 HE Chang;ZHAO Ran;ZHANC Wen;ZHANG Zedan;WEN Xiaoxiao;CU Xinyi;ZHUANG Huiying;WANG Bin(Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Chinese Medicine Science and Technology Cooperation Center,China Academy of Chinese Medicine Sciences,Beijing 100700,China;National Data Center of Traditional Chinese Medicine,China Academy of Chinese Medicine Sciences,Beijing 100700,China;Experimental Research Center,China Academy of Chinese Medical Sciences,Beijing 100700,China;School of Public Health,Inner Mogolia Minzu University,Tongliao 015099,Inner Mogolia,China)

机构地区：[1]中国中医科学院中医药信息研究所,北京100700 [2]中国中医科学院中医药科技合作中心,北京100700 [3]中国中医科学院中医药数据中心,北京100700 [4]中国中医科学院医学实验中心,北京100700 [5]内蒙古民族大学公共卫生学院,内蒙古通辽015099

出　　处：《中华中医药学刊》2025年第4期18-25,共8页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(82274685);中国中医科学院科技创新工程重大攻关项目(CI2021A01009)。

摘　　要：区块链和安全多方计算协议可以解决数据共享时的安全隐私问题。区块链确保计算过程的可追溯性,防止恶意节点篡改上传数据;安全多方计算协议将互不可信的用户作为参与方整合起来,建立安全可靠的合作机制。基于区块链和安全多方计算协议设计中医药临床数据分布式算法能整合来自多方的临床数据,扩大研究样本量,解决目前中医药临床数据共享存在的“不愿,不敢,不能”问题,促进中医药真实世界研究的发展。创造性地将频数分析与描述性统计融入安全多方计算协议,融合了区块链技术增强数据共享的安全性和透明度,为中医药临床数据设计了一套高效且保护隐私的分布式计算方案。分析了该方案相较于集中式计算在数据安全和隐私保护方面的优势,还设计实验证明了该方案在计算真实中医临床数据时的准确性和可行性。该方案为中医药领域的数据共享开创了新方向,既保障了患者隐私,又实现了临床数据的有效聚合,加速了中医药现代化和科学化进程。Blockchain and secure multi-party computation(SMPC)are feasible ways to solve security and privacy issues of data sharing.Blockchain ensures the traceability of computing processes and prevents malicious computing party to modify its upload data.The secure multi-party computation protocols can integrate untrustworthy users as participants to establish safe and trusted cooperation mechanism.The design of traditional Chinese medicine(TCM)clinical data algorithm based on blockchain and secure multi-party computing protocols can integrate the multiparty clinical data,expand the research sample size,solve the problem of“being unwilling,afraid and unable”to share TCM clinical data and promote the development of TCM real-world study.This article creatively integrated frequency analysis and descriptive statistics into SMPC protocols,integrated blockchain technology to enhance the security and transparency of data sharing,so as to design a set of efficient and privacy-protecting distributed computation scheme for TCM clinical data.This article not only analyzed the advantages of this scheme in data security and privacy protection compared with centralized computation,but also designed experiments to prove the accuracy and feasibility of this scheme in calculating real TCM clinical data.The scheme creates a new direction for TCM data sharing,which not only guarantees patient privacy,but also realizes effective aggregation of clinical data,and accelerates the modernization and scientific process of TCM.

关 键 词：中医药临床数据 数据共享 区块链 安全多方计算 分布式算法 

分 类 号：R241[医药卫生—中医诊断学]