基于铁死亡探讨“阳气亏虚,脾肾虚冷”与年龄相关疾病内在联系及附子的应用相关研究进展  

Discussion on Internal Relationship between Theory of“Deficiency of Yang Qi,Deficiency and Cold of Spleen and Kidney”and Age-Related Diseases Based on ferroptosis and Research Progress in Application of Fuzi(Aconiti Lateralis Radix Praeparata)

作　　者：张美菱 王琪格 王杰[1] 裘雪莹 宋囡[1] 隋国媛 王佳[1] 贾连群[1] ZHANG Meiling;WANG Qige;WANG Jie;QIU Xueying;SONG Nan;SUI Guoyuan;WANG Jia;JIA Lianqun(Ministry of Education Key Laboratory of Visceral Phenomenon Theory and Application in Traditional Chinese Medicine,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China)

机构地区：[1]辽宁中医药大学中医脏象理论及应用教育部重点实验室,辽宁沈阳110847

出　　处：《中华中医药学刊》2025年第4期105-108,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82074145,81974548);辽宁省“兴辽英才计划”项目(XLYC1902100);辽宁省教育厅科学研究面上项目(LJKZ0877)。

摘　　要：衰老是细胞持续丢失,组织与器官功能逐步发生退行性改变的生物学过程,在此过程中发病率随年龄增长呈指数级上升的一类疾病称为年龄相关疾病(age-related diseases,ARDs)。人至中年,阳气渐衰,脾肾虚冷为甚,虚与痰瘀毒交织,是ARDs发生的关键病机。铁死亡属于铁依赖性非凋亡程序性死亡,年龄相关的铁稳态和氧化还原失衡使其在ARDs发生发展中成为关键环节,是从脾肾论治ARDs现代生物学内涵的重要组成部分,包含“脾阳不足,运化无主”与线粒体铁稳态失衡相关性、“肾阳失煦,元气失化”与氧化还原失衡相关性两个方面。以铁死亡为切入点丰富中医理论对ARDs的认识,并对于近年来附子在临床及基础研究中的进展进行总结,旨在为衰老水平相关疾病的中西医机制研究提供新思考。Aging is a biological process in which cells continue to lose and tissue and organ functions gradually undergo degenerative changes.In this process,a class of diseases whose incidence rate increases exponentially with age are called age-related diseases(ARDs).In middle age,the gradual decline of Yangqi,spleen deficiency,kidney deficiency and coldness are the key pathological mechanisms for the occurrence of ARDS.Ferroptosis belongs to iron dependent non apoptotic programmed death.Age related iron homeostasis and redox imbalance make it a key link in the occurrence and development of ARDs.It is an important part of the modern biological connotation of treating ARDs from spleen and kidney,including the correlation between“deficiency of spleen Yang,lack of transportation”and mitochondrial iron homeostasis imbalance,and the correlation between“deficiency of kidney Yang,loss of vital Qi”and redox imbalance.Taking ferroptosis as the breakthrough point,this article enriched the understanding of traditional Chinese medicine theory on ARDs,and summarized the progress of Fuzi(Aconiti Lateralis Radix Praeparata)in clinical and basic research in recent years,aiming to provide new thinking for the study of the mechanism of traditional Chinese medicine and western medicine of ARDs.

关 键 词：年龄相关性疾病 阳气亏虚 脾肾虚冷 铁死亡机制 附子 

分 类 号：R282.71[医药卫生—中药学]