土茯苓的质量控制现状及质量标志物预测分析  

Quality Control Status and Prediction Analysis of Quality Markers of Tufuling(Smilacis Glabrae Rhizoma)

作　　者：彭嘉文 谢晶晶 马玉明 郑飘雪 梁炎丽 陆春莲 朱华[1,3] 梁洁 PENG Jiawen;XIE Jingjing;MA Yuming;ZHENG Piaoxue;LIANG Yanli;LU Chunlan;HU Hua;LIANG Jie(Guangxi University of Chinese Medicine,Nanning 530200,Guangxi,China;Key Laboratory of TCM Extraction and Purification and Quality Analysis,Education Department of Guangxi Zhuang Autonomous Region,Nanning 530200,Guangxi,China;Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine,Nanning 530200,Guangxi,China)

机构地区：[1]广西中医药大学,广西南宁530200 [2]广西高校中药提取纯化与质量分析重点实验室,广西南宁530200 [3]广西壮瑶药重点实验室,广西南宁530200

出　　处：《中华中医药学刊》2025年第4期181-186,共6页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82160771);国家中医药管理局高水平中医药重点学科建设项目-少数民族药学(壮药学)(zyyzdxk-2023165);广西壮瑶药重点实验室项目(桂科基字[2014]32号);广西中医药多学科交叉创新团队项目(GZKJ2309);广西高等学校千名中青年骨干教师培育计划项目(桂教人[2019]5号);壮瑶药协同创新中心项目(桂教科研[2013]20号);广西壮族自治区民族药资源与应用工程研究中心项目(桂发改高技函[2020]2605号);广西重点研发计划项目(桂科AB21196016);广西中医药重点学科壮药学项目(GZXK-Z-20-64);广西一流学科中药学项目(民族药学)(桂教科研[2018]12号);广西科技基地和人才专项(桂科AD20238058,桂科AD21238031);广西中医药大学第三批“岐黄工程”高层次人才团队培育项目(202406)。

摘　　要：土茯苓中含有黄酮类、有机酸类、苯丙素类、糖类、挥发油类等多种化学成分。现代药理研究表明,土茯苓具有抗炎、镇痛、抗菌、抑菌、降尿酸、免疫、抗肿瘤等药理作用,临床应用前景良好。概括了土茯苓的质量控制现状,从植物亲缘学及化学成分可测性、不同配伍环境、不同产地及不同生长年限、不同加工方法、传统功效、传统药性、药动学、新的药效用途共8个方面对土茯苓的质量标志物进行了预测分析,可考虑将落新妇苷、新落新妇苷、黄杞苷、槲皮素等成分作为土茯苓质量标志物的选择对象,为建立和完善土茯苓的质量标准提供参考和依据。Tufuling(Smilacis Glabrae Rhizoma)contains various chemical components such as flavonoids,organic acids,phenylpropanoids,sugars,volatile oils and sugars.Modern pharmacological studies have shown that Tufuling(Smilacis Glabrae Rhizoma)has anti-inflammatory,analgesic,antibacterial,antibacterial,lowering uric acid,immune,anti-tumor and other pharmacological effects,and has good clinical application prospects.This paper summarized the current status of quality control of Tufuling(Smilacis Glabrae Rhizoma),and predictive analysis was conducted on the quality markers of Tufuling(Smilacis Glabrae Rhizoma)from plant phylogeny and testability of chemical components,different compatibility environments,different origins and growth years,different processing methods,traditional efficacy,traditional medicinal properties,pharmacokinetics and new pharmacological uses.It can be considered that the components such as astilbin,neoastilbin,engeletin and quercetin were selected as the quality markers of Tufuling(Smilacis Glabrae Rhizoma),to provide reference and basis for establishing and improving the quality standards of Tufuling(Smilacis Glabrae Rhizoma).

关 键 词：土茯苓 质量标志物 预测分析 

分 类 号：R284.1[医药卫生—中药学]