轮状病毒感染性腹泻患儿血清C反应蛋白、心肌酶谱及肝功能检测的临床意义  

Clinical Significance of Detection of Serum C-reactive Protein,Myocardial Enzyme Spectrum and Liver Function in Children with Rotavirus Infectious Diarrhea

作　　者：王丽远 WANG Li-yuan(Third Affiliated Hospital of Nanyang Medical College,Nanyang,Henan 473043)

机构地区：[1]南阳医学专科学校第三附属医院,河南南阳473043

出　　处：《中国肛肠病杂志》2025年第2期31-33,共3页Chinese Journal of Coloproctology

摘　　要：目的:探讨轮状病毒(RV)感染性腹泻患儿血清C反应蛋白(CRP)、心肌酶谱及肝功能检测的临床意义。方法:选取2024年2~8月我院收治的RV感染性腹泻患儿、细菌感染性腹泻患儿及同期健康体检幼儿各50人纳入研究。比较RV感染性腹泻患儿及细菌感染性腹泻患儿肠外损伤情况,比较3组受试者CRP、白介素-6(IL-6)、心肌肌钙蛋白T(cTnT)、肌酸激酶(CK)、肌酸激酶同工酶MB(CK-MB)、门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)水平。结果:RV感染性腹泻组下呼吸道感染、皮疹、心肌损伤、肝功能损伤发生率明显高于细菌感染性腹泻组,P<0.05。血清CRP、IL-6水平,RV感染性腹泻组和细菌感染性腹泻组明显高于健康组(P<0.05),RV感染性腹泻组明显低于细菌感染性腹泻组(P<0.05)。cTnT、CK、CK-MB、AST、ALT水平,RV感染性腹泻组明显高于细菌感染性腹泻组和健康组(P<0.05),细菌感染性腹泻组和健康组比较差异无统计学意义(P>0.05)。结论:血清CRP、肝功能和心肌酶谱检测对RV感染性腹泻患儿的诊断具有一定参考价值,值得进一步深入研究。Objective To investigate the clinical significance of serum C-reactive protein(CRP),myocardial enzymes and liver function in children with rotavirus(RV)infectious diarrhea.MethodsA total of 50 children with RV infectious diarrhea,50 children with bacterial infectious diarrhea and 50 healthy chil-dren who underwent physical examination in our hospital from February to August 2024 were enrolled in the study.Extraintestinal injury was compared between children with RV infectious diarrhea and children with bacterial infectious diarrhea.The levels of CRP,interleukin-6(IL-6),troponin(cTnT),creatine kinase(CK),creatine kinase isoenzyme(CK-MB),aspartate aminotransferase(AST),and alanine aminotransferase(ALT)were compared among the three groups.Results Compared with the bacterial infectious diarrhea group,the RV infectious diarrhea group had significantly higher incidence rates of lower respiratory tract infection,rash,myocardial injury,and liver function damage(P<0.05).The levels of serum CRP and IL-6 in the RV infectious diarrhea group and bacterial infectious diarrhea group were significantly higher than those in the healthy group(P<0.05),and the levels of serum CRP and IL-6 in the RV infectious diarrhea group were significantly lower than those in the bacterial infectious diarrhea group(P<0.05).The levels of cTnT,CK,CK-MB,AST,and ALT in the RV infectious diarrhea group were significantly higher than those in the bacterial infectious diarrhea group and the healthy group(P<O.05),but there was no significant difference between the bacterial infectious diarrhea group and the healthy group(P>0.05).Conclusion The detection of serum CRP,liver function and myocardial enzyme spectrum has certain reference value for the diagnosis of children with RV infectious diarrhea,which is worthy of further in-depth study.

关 键 词：腹泻 轮状病毒感染 细菌感染 诊断 

分 类 号：R725.7[医药卫生—儿科]