加味左金丸联合奥美拉唑治疗反流性咽喉炎的 临床效果  

Clinical Effect of Modified Zuojin Pills Combined with Omeprazole in the Treatment of Reflux Pharyngitis

作　　者：李刚 左尔东 陈新军[1] LI Gang;ZUO Erdong;CHEN Xinjun(Capital Medical University Affiliated Beijing Tongren Hospital Mentougou Hospital,Beijing 102300,China)

机构地区：[1]首都医科大学附属北京同仁医院门头沟医院,北京102300

出　　处：《中外医学研究》2025年第8期26-30,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:观察加味左金丸联合奥美拉唑治疗反流性咽喉炎的临床效果,为今后临床治疗提供有利的参考依据。方法:选取2019年3月—2023年5月首都医科大学附属北京同仁医院门头沟医院收治的86例反流性咽喉炎患者,以随机数表法分成两组,对照组(n=43)采取奥美拉唑治疗,观察组(n=43)在奥美拉唑基础上,采取加味左金丸治疗。对比两组疗效、治疗前后喉黏液胃蛋白酶浓度、反流症状指数量表(RSI)评分、反流体征评分量表(RFS)评分、症状评分、体征评分及胃肠激素指标,记录用药期间不良反应。结果:观察组总有效率为93.02%(40/43),高于对照组的69.77%(30/43),差异有统计学意义(P<0.05)。两组治疗后喉黏液胃蛋白酶浓度、RSI评分、RFS评分、症状评分、体征评分、胃蛋白酶原Ⅰ(PGⅠ)、促胃泌素(GAS)水平均低于治疗前,且观察组低于对照组,促胃动素(MTL)均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为11.63%(5/43),对照组为6.98%(3/43),差异无统计学意义(P>0.05)。结论:加味左金丸联合奥美拉唑可进一步改善反流性咽喉炎患者的症状、体征,调节胃肠激素,提高疗效,且安全性较高。Objective:To observe the clinical effect of Modified Zuojin Pills combined with Omeprazole in the treatment of reflux pharyngitis,and to provide a favorable reference for future clinical treatment.Method:Eighty-six patients with reflux pharyngitis admitted to Capital Medical University Affiliated Beijing Tongren Hospital Mentougou Hospital from March 2019 to May 2023 were selected and divided into two groups by random number table method.The control group(n=43)was treated with Omeprazole,and the observation group(n=43)was treated with Modified Zuojin Pills on the basis of Omeprazole.The therapeutic effect,laryngeal mucous pepsin concentration,reflux symptom index scale(RSI)score,reflux finding scale(RFS)score,symptom score,signs score and gastrointestinal hormone index before and after treatment of the two groups were compared,and adverse reactions during medication was recorded.Result:The total effective rate was 93.02%(40/43)in the observation group,which was higher than 69.77%(30/43)in the control group,the difference was statistically significant(P<0.05).The laryngeal mucus pepsin concentration,RSI scores,RFS scores,symptom scores,sign scores,pepsinogenⅠ(PGⅠ)and gastrin stimulating hormone(GAS)levels in the two groups after treatment were all lower than those before treatment,and the indexes in the observation group were lower than those in the control group,motilin(MTL)were higher than those before treatment,and the observation group was higher than the control group,the differences were statistically significant(P<0.05).The adverse reaction rate was 11.63%(5/43)in the observation group and 6.98%(3/43)in the control group,the difference was not statistically significant(P>0.05).Conclusion:Modified Zuojin Pills combined with Omeprazole can further improve the symptoms and signs of patients with reflux pharyngitis,regulate gastrointestinal hormones,improve the efficacy and safety.

关 键 词：加味左金丸 奥美拉唑 反流性咽喉炎 胃蛋白酶 反流症状指数量表评分 反流体征量表评分 

分 类 号：R766.5[医药卫生—耳鼻咽喉科]