慢阻肺患者HDAC2、IL-8、TNF-α水平及其临床价值  

Levels of HDAC2,IL-8 and TNF-αin Patients with COPD and the Clinical Value

作　　者：张洁 刘澄英[1] ZHANG Jie;LIU Chengying(Jiangyin People's Hospital,Jiangyin 214400,China)

机构地区：[1]江阴市人民医院,江苏江阴214400

出　　处：《中外医学研究》2025年第9期16-19,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究慢性阻塞性肺疾病患者生化检测中组蛋白脱乙酰基酶2(HDAC2)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平的实际情况,并分析各项指标水平与病情的关系及对疾病治疗效果的评估价值。方法:选取2022年1月-2024年5月江阴市人民医院收治的165例慢性阻塞性肺疾病患者作为研究对象设为研究组,另选150例健康成年人设为对照组。比较两组HDAC2、IL-8、TNF-α的水平,比较慢性阻塞性肺疾病发作期、稳定期的HDAC2、IL-8、TNF-α水平。对研究组实施个体化、综合性治疗,比较治疗前后HDAC2、IL-8、TNF-α水平。结果:研究组HDAC2水平低于对照组,IL-8、TNF-α水平高于对照组,差异有统计学意义(P<0.05)。研究组慢性阻塞性肺疾病发作期患者HDAC2检测水平低于对照组,IL-8、TNF-α水平高于对照组,差异有统计学意义(P<0.05)。治疗后,研究组HDAC2检测水平较治疗前升高,IL-8、TNF-α水平较治疗前下降,差异有统计学意义(P<0.05)。结论:HDAC2、IL-8、TNF-α水平可以作为慢性阻塞性肺疾病诊断依据,能够评估病情严重程度,为疾病治疗提供参考。Objective:To explore the biochemical detection of recombinant histone deacetylase 2(HDAC2)and Interleukin-8(IL-8)and Tumor necrosis factor-α(TNF-α)in patients with chronic obstructive pulmonary disease,and analyze the relationship between the level of various indicators and the disease,as well as the evaluation value of the treatment effect of the disease.Method:165 patients with chronic obstructive pulmonary disease treated in Jiangyin People's Hospital from January 2022 to May 2024 were selected as the study group.Another 150 healthy adults were selected as control group.The levels of HDAC2,IL-8 and TNF-αwere compared between the two groups,and the levels of HDAC2,IL-8 and TNF-αwere compared between the attack stage and the stable stage of chronic obstructive pulmonary disease.The levels of HDAC2,IL-8 and TNF-αwere compared before and after treatment.Result:The levels of HDAC2 in the study group were lower than those in the control group,and the levels of IL-8 and TNF-αwere significantly higher than those in the control group(P<0.05).The levels of HDAC2 in patients with COPD were lower than those in control group,and the levels of IL-8 and TNF-αwere higher than those in control group(P<0.05).After treatment,the HDAC2 detection level in the study group was higher than that before treatment,and the IL-8 and TNF-αlevels were lower than that before treatment(P<0.05).Conclusion:The detection levels of HDAC2,IL-8 and TNF-αcan be used as diagnostic basis for chronic obstructive pulmonary disease,and can evaluate the severity of the disease and provide reference for the treatment of the disease.

关 键 词：慢性阻塞性肺疾病 组蛋白脱乙酰基酶2 白细胞介素-8 肿瘤坏死因子-Α 

分 类 号：R563[医药卫生—呼吸系统]