探讨转变体位干预联合经鼻高流量湿化氧疗对新生儿肺炎IL-6、CRP及血氧的影响  

To Investigate the Effects of Changing Position Intervention Combined with Nasal High Flow Humidification Oxygen Therapy on IL-6,CRP and Blood Oxygen in Neonates with Pneumonia

作　　者：叶丽云 YE Liyun(Nanping First Hospital,Nanping 353000,China)

机构地区：[1]南平市第一医院,福建南平353000

出　　处：《中外医学研究》2025年第9期101-104,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨转变体位干预联合经鼻高流量湿化氧疗(HFNC)对新生儿肺炎患儿血清白介素-6(IL-6)、C-反应蛋白(CRP)及血氧的影响。方法:选取2021年1月-2022年12月南平市第一医院收治的210例新生儿肺炎患者作为研究对象,将其随机分成对照组和观察组,每组各105例。对照组采用HFNC进行治疗,观察组在对照组治疗的基础上增加转变体位干预措施,比较两组治疗前后IL-6、CRP以及血氧指标,比较两组临床症状及疗效。结果:治疗后,观察组IL-6、CRP、二氧化碳分压(PaCO_(2))及氧分压(PaO_(2))水平明显低于对照组,差异有统计学意义(P<0.05);观察组动脉血氧饱和度(SpO_(2))水平明显高于对照组,差异有统计学意义(P<0.05);治疗后,观察组在无创通气、心率恢复、呼吸改善以及住院等时间上明显低于对照组,差异有统计学意义(P<0.05);观察组总有效率显著高于对照组,差异有统计学意义(P<0.05)。结论:转变体位干预联合HFNC可有效降低新生儿肺炎患者炎症水平,改善其血氧指标及临床症状,提高临床疗效。Objective:To explore the effects of positional intervention combined with nasal high-flow humidified oxygen therapy(HFNC)on serum Interleukin IL-6(IL-6),C-Reactive Protein(CRP),and blood oxygen levels in newborns with pneumonia.Method:210 newborns with pneumonia treated in our hospital from January 2021 to December 2022 were selected as the subjects of this study and randomly divided into control group and observation group,with 105 cases in each group.The control group was treated with HFNC,and the observation group added positional intervention measures on the basis of the treatment in the control group.The IL-6,C-reactive protein,and blood oxygen indexes before and after treatment in the two groups were compared,and the clinical symptoms and efficacy of the two groups of patients were compared.Result:After treatment,the levels of IL-6,CRP,carbon dioxide partial pressure(PaCO2)and oxygen partial pressure(PaO2)in observation group were significantly lower than those in control group,with statistical significance(P<0.05).The level of arterial oxygen saturation(SpO2)in the observation group was significantly higher than that in the control group,with statistical significance(P<0.05).After treatment,the duration of non-invasive ventilation,heart rate recovery,respiratory improvement and hospitalization in the observation group was significantly lower than that in the control group,with statistical significance(P<0.05).The total effective rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:Positional intervention combined with HFNC can effectively reduce the inflammation level of newborns with pneumonia,improve their blood oxygen indicators and clinical symptoms,and improve their clinical efficacy.

关 键 词：转变体位 经鼻高流量湿化氧疗 新生儿肺炎 

分 类 号：R722.1[医药卫生—儿科]