超脉冲CO_(2)点阵激光联合复方甘草酸苷片对白癜风患者的临床疗效  

Clinical Efficacy of Ultra Pulsed CO2 Lattice Laser combined with Compound Glycyrrhizin on Patients with Vitiligo

作　　者：崔兴芳 翟虹 CUI Xingfang;ZHAI Hong(Liupanshui People's Hospital,Liupanshui 553001,China)

机构地区：[1]六盘水市人民医院,贵州六盘水553001

出　　处：《中外医学研究》2025年第9期137-141,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究超脉冲CO_(2)点阵激光联合复方甘草酸苷片对白癜风患者的临床疗效。方法:选取2022年1月-2023年10月于六盘水市人民医院就诊的84例白癜风患者作为研究对象,采用随机数表法分为研究组和对照组,每组各42例。对照组采取超脉冲CO_(2)点阵激光治疗,研究组采取超脉冲CO_(2)点阵激光联合复方甘草酸苷片治疗。干预6个月后,观察两组临床疗效,对比两组白斑面积、皮损复色率,免疫指标、炎症指标及不良反应发生情况。结果:研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,研究组白斑面积小于对照组,皮损复色率高于对照组,血清白细胞介素-17(IL-17)、白细胞介素-23(IL-23)、CD8^(+)水平低于对照组,CD3^(+)、CD4^(+)水平高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:超脉冲CO_(2)点阵激光联合复方甘草酸苷片治疗白癜风,能够有效减少患者白斑面积,改善患者免疫及炎性指标,安全性较高,有较好的临床疗效。Objective:To explore the clinical effect of superpulse CO_(2) lattice laser combined with compound glycyrrhizin on patients with vitiligo.Method:A total of 84 patients with vitiligo who were treated in Liupanshui People's Hospital from January 2022 to October 2023 were selected as the study objects and divided into study group and control group by random number table method,with 42 cases in each group.The control group was treated with superpulse CO_(2) lattice laser,and the study group was treated with superpulse CO_(2) lattice laser combined with compound glycyrrhizin.After 6 months of intervention,the clinical efficacy of the two groups was observed,and the white spot area,skin recolor rate,immune indexes,inflammatory indexes and the occurrence of adverse reactions were compared between the two groups.Result:The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the white plaque area of the study group was smaller than that of the control group,the recolor rate of skin lesions was higher than that of the+control group,the levels of serum interleukin-17(IL-17),interleukin-23(IL-23)and CD8^(+) were lower than those of the control group,and the levels of CD3^(+) and CD4^(+) were higher than those of the control group,with statistical significance(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Superpulse CO_(2) lattice laser combined with compound glycyrrhizin tablets can effectively reduce the patient's white spot area,improve the patient's immune and inflammatory indexes,with high safety and good clinical efficacy.

关 键 词：超脉冲CO_(2)点阵激光 复方甘草酸苷片 白癜风 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]