利奈唑胺与环丝氨酸胶囊对肺结核的X-pert MTB/RIF检测结果变化及肺功能的影响  

Changes in X-pert MTB/RIF Test Results and Effects on Lung Function of Linezolid and Cycloserine Capsules on Pulmonary Tuberculosis

作　　者：蔡煌杰 林成祖 蔡冰 CAI Huangjie;LIN Chengzu;CAI Bing(Jinjiang Hospital,Jinjiang 362200,China)

机构地区：[1]晋江市医院(上海市第六人民医院福建医院),福建晋江362200

出　　处：《中外医学研究》2025年第9期141-144,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析耐多药肺结核患者行利奈唑胺、环丝氨酸胶囊联合治疗对X-pert MTB/RIF检测结果、肺功能水平影响。方法:选取2021年7月-2023年6月晋江市医院收治的79例耐多药肺结核患者为研究对象,进行回顾性治疗研究,患者均于期间接受研究用药物治疗,以利奈唑胺治疗者为参照组(39例),以利奈唑胺、环丝氨酸胶囊联合治疗者为研究组(40例)。比较两组治疗前后肺通气功能水平,细胞免疫功能水平;治疗后X-pert MTB/RIF检测结果,临床症状改善时间,痰结核杆菌转阴率,治疗有效率以及药物不良反应发生率情况。结果:相较参照组,研究组经环丝氨酸联合治疗的肺通气功能水平及CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)升高,差异有统计学意义(P<0.05);X-pert MTB/RIF阳性检出率(15.00%)降低,痰结核杆菌转阴率(85.00%)、治疗有效率(92.50%)升高,差异有统计学意义(P<0.05);病灶面积缩小时间、痰培养转阴时间、抗酸染色涂片转阴时间及肺部空洞闭合时间缩短,差异有统计学意义(P<0.05);两组药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论:耐多药肺结核患者行利奈唑胺、环丝氨酸胶囊联合治疗效果确切,可降低X-pert MTB/RIF阳性检出率,促进痰结核杆菌转阴,并调节患者肺功能、细胞免疫功能,无明显毒副反应风险,具备临床用药安全性。Objective:To analyze the effects of combination therapy with linezolid and cycloserine capsules on X-pert MTB/RIF test results and lung function levels in patients with multidrug-resistant pulmonary tuberculosis.Method:79 patients with multidrug-resistant tuberculosis admitted to Jinjiang Hospital from July 2021 to June 2023 were selected as the study objects for retrospective treatment study.All patients received investigatory drug treatment during this period.The patients treated with Elinezolid were the reference group(39 cases),and the patients treated with Elinezolid combined with cycloserine capsule were the study group(40 cases).The levels of lung ventilation function and cellular immune function before and after treatment were compared between the two groups.After treatment,the results of X-pert MTB/RIF detection,the improvement time of clinical symptoms,the negative conversion rate of tuberculosis in sputum,the effective rate of treatment and the incidence of adverse drug reactions.Result:Compared with the control group,the levels of ventilatory function,CD4^(+),CD8^(+) and CD4^(+)/CD8^(+)in the study group after cycloserine combined treatment were increased,and the differences were statistically significant(P<0.05).The positive detection rate of X-pert MTB/RIF was decreased(15.00%),the negative conversion rate of sputum tuberculosis bacillus was increased(85.00%),and the effective rate of treatment was increased(92.50%),with statistical significance(P<0.05).The time of focal area reduction,sputum culture to negative time,acid-fast staining smear to negative time and pulmonary cavity closure time were shortened,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups(P>0.05).Conclusion:The combined treatment of linezolid and cycloserine capsule in patients with MDR-TB has a definite effect,which can reduce the positive detection rate of X-pert MTB/RIF,promote the negative transformation of sputum tuber

关 键 词：利奈唑胺 环丝氨酸 多耐药肺结核 X-pert MTB/RIF 肺功能 

分 类 号：R521[医药卫生—内科学]