楂曲合剂治疗餐后不适综合征38例  

Clinical effect of Zhaqu mixture in treatment of postprandial distress syndrome:An analysis of 38 cases

作　　者：唐莉[1] 蔡燕峰[1] 杨勤[1] 杨洁[1] TANG Li;CAI Yanfeng;YANG Qin;YANG Jie(Nanjing Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing 210022,Jiangsu,China)

机构地区：[1]南京中医药大学附属南京中医院,江苏南京210022

出　　处：《湖南中医杂志》2025年第2期6-10,共5页Hunan Journal of Traditional Chinese Medicine

基　　金：江苏省中医药科技发展计划面上项目(MS2023055);南京卫生科技发展专项重点项目(ZKX21058);杨勤名中医工作室(2023-NJSMZYGZS-YQ)。

摘　　要：目的:观察院内制剂楂曲合剂治疗餐后不适综合征(PDS)饮食内停证的临床疗效。方法:将80例PDS饮食内停证患者随机分为治疗组和对照组,每组各40例。治疗组予以楂曲合剂治疗,对照组予以复方阿嗪米特肠溶片治疗,比较2组治疗前后功能性消化不良(FD)症状程度评分(FD症状严重程度、FD症状发作频率及FD症状程度总评分)、中医证候总积分、中医脾胃病医生报告结局(ClinRO)症状量表评分(胃系症状评分、全身症状评分和ClinRO总评分),并评价综合疗效。结果:治疗过程中治疗组脱落2例,对照组脱落3例。总有效率治疗组为89.50%(34/38),对照组为86.50%(32/37),2组比较,差异无统计学意义(P>0.05)。2组治疗后FD症状程度各项评分、中医证候总积分、ClinRO各项评分均低于治疗前(P<0.01),其中治疗组FD症状发作频率评分、FD症状程度总评分、中医证候总积分、胃系症状评分及ClinRO总评分均低于对照组(P<0.05)。结论:楂曲合剂可明显改善PDS饮食内停证患者的临床症状,缓解餐后饱胀、早饱的症状程度,并减少其发作频率,亦可改善患者整体健康状态。Objective:To investigate the clinical effect of the hospital-made prescription Zhaqu mixture in the treatment of postprandial distress syndrome(PDS)with internal stagnation of food.Methods:A total of 80 PDS patients with internal stagnation of food were randomly divided into treatment group and control group,with 40 pa-tients in each group.The patients in the treatment group were given Zhaqu mixture,and those in the control group were given compound azintamide enteric-coated tablets.The two groups were compared in terms of functional dys-pepsia(FD)symptom scores(the severity,frequency,and total score of FD symptoms),total traditional Chinese medicine(TCM)syndrome score,clinican-reported outcome(ClinRO)symptom scale score for spleen and stom-ach discorders in TCM(gastric symptom score,systemic symptom score,and total ClinRO score)before and after treatment,and overall response was evaluated.Results:Two patients in the treatment group and three in the control group were lost to follow-up during treatment.There was no significant difference in overall response rate between the treatment group and the control group[89.50%(34/38)vs 86.50%(32/37),P>0.05].After treatment,both groups had significant reductions in FD symptom scores,total TCM syndrome score,and ClinRO scores(P<0.01),and compared with the control group,the treatment group had significantly lower FD symptom frequency score,total FD symptom score,total TCM syndrome score,gastric symptom score,and total ClinRO score(P<0.05).Conclusion:Zhaqu mixture can significantly improve the clinical symptoms of PDS patients with internal stagnation of food,alleviate the symptoms of postprandial fullness and early satiety,reduce the frequency of symp-toms,and improve the overall health status.

关 键 词：餐后不适综合征 功能性消化不良 饮食内停证 楂曲合剂 疗效评价 

分 类 号：R259.7[医药卫生—中西医结合]