经鼻持续气道正压通气对重症新生儿肺炎的治疗作用研究  

Study on the Therapeutic Effect of Nasal Continuous Positive Airway Pres⁃sure on Severe Neonatal Pneumonia

作　　者：李银玲 倪金龙[1] 张敏 LI Yinling;NI Jinlong;ZHANG Min(Neonatal Department,Tengzhou Maternal and Child Health Hospital,Tengzhou,Shandong,277500,China)

机构地区：[1]滕州市妇幼保健院新生儿科,山东滕州277500

出　　处：《中外医疗》2025年第2期18-22,共5页China & Foreign Medical Treatment

摘　　要：目的 分析经鼻持续气道正压通气治疗重症新生儿肺炎的效果。方法 随机选取2023年1月—2024年1月滕州市妇幼保健院收治的80例重症新生儿肺炎患儿作为研究对象,依据不同治疗方法分为对照组和观察组,各40例,对照组给予头罩或鼻导管吸氧,观察组给予经鼻持续气道正压通气,对比两组的呼吸功能、症状消失时间及住院时间、炎症因子水平、治疗有效率、氧疗舒适度和不良反应发生情况。结果 治疗后,观察组呼吸频率与心率、动脉血二氧化碳分压(partial pressure of carbon dioxide,PaCO_(2))低于对照组,动脉血氧分压(pulmonary arterial oxygen tension,PaO2)高于对照组,差异均有统计学意义(P均<0.05)。观察组症状消失及住院时间短于对照组,差异均有统计意义(P均<0.05)。治疗后,观察组炎性因子水平优于对照组,差异有统计学意义(P<0.05)。观察组总有效率为100.00%(40/40),高于对照组的85.00%(34/40),差异有统计学意义(χ^(2)=4.505,P=0.034)。氧疗12 h、24 h和48 h,观察组氧疗舒适度均优于对照组,差异均有统计学意义(P均<0.05)。观察组不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论 在重症新生儿肺炎治疗中使用经鼻持续气道正压通气在改善呼吸功能、减轻症状、抑制炎症方面优势显著,且舒适度较高、不良反应较少。Objective To analyze the effect of nasal continuous positive airway pressure in the treatment of severe neonatal pneumonia.Methods A total of 80 children with severe neonatal pneumonia admitted to Tengzhou Maternal and Child Health Hospital from January 2023 to January 2024 were randomly selected as the research objects.According to different treatment methods,they were divided into control group and observation group,with 40 cases in each group.The control group was given hood or nasal catheter oxygen inhalation,and the observation group was given nasal continuous positive airway pressure.The respiratory function,symptom disappearance time and hospitalization time,inflammatory factor level,treatment efficiency,oxygen therapy comfort and adverse reactions were compared between the two groups.Results After treatment,the respiratory rate,heart rate and partial pressure of carbon dioxide(PaCO_(2))in the observation group were lower than those in the control group,and the pulmonary arterial oxygen tension(PaO2)was higher than that in the control group,the differences were statistically significant(all P<0.05).The disappearance of symptoms and hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(both P<0.05).After treatment,the level of inflammatory factors in the observation group was better than that in the control group,and the difference was statistically significant(P<0.05).The total effective rate of the observation group was 100.00%(40/40),which was higher than 85.00%(34/40)of the control group,and the difference was statistically significant(χ^(2)=4.505,P=0.034).At 12 hours,24 hours and 48 hours after oxygen therapy,the comfort of oxygen therapy in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significa

关 键 词：经鼻持续气道正压通气 重症新生儿肺炎 呼吸功能 

分 类 号：R72[医药卫生—儿科]