慢性阻塞性肺疾病肺气肿患者应用甲泼尼龙联合二羟丙茶碱治疗的效果  

Effect of Methylprednisolone and Diprophylline in Patients with Chronic Obstructive Pulmonary Disease Emphysema

作　　者：李静 韩林 山长红 黄娜 LI Jing;HAN Lin;SHAN Changhong;HUANG Na(Department of Respiratory and Critical Care Medicine,Jining Yanzhou District People´s Hospital,Jining,Shandong,272100,China)

机构地区：[1]济宁市兖州区人民医院呼吸与危重症医学科,山东济宁272100

出　　处：《中外医疗》2025年第2期75-78,共4页China & Foreign Medical Treatment

摘　　要：目的 探究甲泼尼龙联合二羟丙茶碱在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)肺气肿患者中的应用效果。方法 随机选取2022年1月—2023年12月济宁市兖州区人民医院收治的60例COPD肺气肿患者为研究对象,按照不同用药方法分为对照组和观察组,每组30例。对照组接受二羟丙茶碱治疗,观察组接受甲泼尼龙联合二羟丙茶碱治疗。比较两组患者的临床疗效、肺部功能、血气指标、不良反应。结果 观察组治疗总有效率为96.67%(29/30),高于对照组的73.33%(22/30),差异有统计学意义(χ^(2)=4.706,P<0.05)。观察组肺功能指标、动脉氧分压水平均高于对照组,动脉二氧化碳分压水平低于对照组,差异均有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 COPD肺气肿患者应用甲泼尼龙联合二羟丙茶碱治疗,可有效提高患者治疗有效率、改善肺部功能及血气指标,且安全性较好。Objective To investigate the application effect of methylprednisolone combined with diprophylline in patients with chronic obstructive pulmonary disease(COPD)and emphysema.Methods From January 2022 to December 2023,60 patients with COPD emphysema admitted to Jining Yanzhou District People´s Hospital were randomly selected as the research objects.According to different medication methods,they were divided into control group and observation group,with 30 cases in each group.The control group was treated with diprophylline,and the observation group was treated with methylprednisolone combined with diprophylline.The clinical efficacy,pulmonary function,blood gas index and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 96.67%(29/30),which was higher than 73.33%(22/30)in the control group,and the difference was statistically significant(χ^(2)=4.706,P<0.05).The pulmonary function index and arterial partial pressure of oxygen in the observation group were higher than those in the control group,and the arterial partial pressure of carbon dioxide was lower than that in the control group,the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The treatment of COPD emphysema patients with methylprednisolone combined with diprophylline can effectively improve the clinical efficacy,improve lung function and blood gas indicators,and has good safety.

关 键 词：肺气肿 甲泼尼龙 二羟丙茶碱 肺部功能 血气指标 

分 类 号：R563[医药卫生—呼吸系统]