水合氯醛保留灌肠在小儿热性惊厥急救中的应用效果评价  

Evaluation of the Application Effect of Chloral Hydrate Retention Enema in Pediatric Febrile Convulsions First Aid

作　　者：赵静静 刘兆国 ZHAO Jingjing;LIU Zhaoguo(Department of Pediatrics,Liaocheng Maternal and Child Health Hospital,Liaocheng,Shandong,252000,China)

机构地区：[1]聊城市妇幼保健院儿科,山东聊城252000

出　　处：《中外医疗》2025年第2期79-83,共5页China & Foreign Medical Treatment

摘　　要：目的 探讨水合氯醛保留灌肠在小儿热性惊厥急救中的应用效果。方法 回顾性选取2023年2月—2024年2月聊城市妇幼保健院接受急救的100例小儿热性惊厥患儿的临床资料。以不同治疗方法分组,每组50例。常规组采用地西泮静脉推注治疗,探究组采用水合氯醛保留灌肠治疗。对比两组炎症反应水平、神经因子水平、症状消失时间及并发症总发生率。结果 治疗后,探究组降钙素原、C反应蛋白、白细胞介素-6均低于常规组,差异均有统计学意义(P均<0.05);探究组S-100β蛋白、神经元特异性烯醇化酶和神经肽Y均优于常规组,差异均有统计学意义(P均<0.05);探究组惊厥、面色发绀、高热、呼吸不规则的症状消失时间均短于常规组,差异均有统计学意义(P均<0.05)。探究组的并发症总发生率为4.00%(2/50),低于常规组的16.00%(8/50),差异有统计学意义(χ^(2)=4.000,P<0.05)。结论 水合氯醛保留灌肠在小儿热性惊厥急救中表现出较好的应用效果,与常规地西泮静脉推注治疗相比,能够更有效地降低炎症反应水平,改善神经因子水平,缩短症状消失时间,并降低并发症总发生率。Objective To explore the application effect of chloral hydrate retention enema in pediatric febrile convulsions emergency treatment.Methods The clinical data of 100 children with febrile convulsion who received first aid in Liaocheng Maternal and Child Health Hospital from February 2023 to February 2024 were retrospectively selected.Grouped by different treatment methods,50 cases in each group.The conventional group was treated with diazepam intravenous injection,and the exploration group was treated with chloral hydrate retention enema.The inflammatory response level,nerve factor level,symptom disappearance time and total complication rate were compared between the two groups.Results After treatment,the levels of procalcitonin,C-reactive protein and interleukin-6 in the exploration group were lower than those in the conventional group,and the differences were statistically significant(all P<0.05);the S-100βprotein,neuron-specific enolase and neuropeptide Y in the exploration group were better than those in the conventional group,and the differences were statistically significant(all P<0.05);the disappearance time of convulsion,cyanosis,high fever and irregular breathing in the exploration group were shorter than those in the conventional group,the differences were statistically significant(all P<0.05).The total incidence of complications in the exploration group was 4.00%(2/50)lower than that in the conventional group 16.00%(8/50),and the difference was statistically significant(χ^(2)=4.000,P<0.05).Conclusion Chloral hydrate retention enema showed great application ef‐fect in pediatric febrile convulsions emergency treatment,which could reduce the level of inflammatory response,improve the level of neurofactors,shorten the time of symptom disappearance,and reduce the total complication rate more effectively than conventional diazepam intravenous push treatment.

关 键 词：水合氯醛 保留灌肠 小儿热性惊厥 急救 应用效果 

分 类 号：R720.5[医药卫生—儿科]