小儿亚临床甲减应用左甲状腺素小剂量给药的应用效果  

Application Effect of Low-dose Administration of Levothyroxine in Chil⁃dren with Subclinical Hypothyroidism

作　　者：孙岩森 朴锦善 刘微 SUN Yansen;PIAO Jinshan;LIU Wei(Department of Pediatric Endocrinology and Hematology(Six Treatment Zones),Jilin Children's Hospital,Jilin,Jilin 132001,China)

机构地区：[1]吉林市儿童医院小儿内分泌及血液科(六疗区),吉林吉林132001

出　　处：《中外医疗》2025年第3期80-84,共5页China & Foreign Medical Treatment

摘　　要：目的 研究小儿亚临床甲状腺功能减退(简称甲减)应用左甲状腺素小剂量给药的应用效果。方法 方便选取2023年1月—2024年6月吉林市儿童医院收治的98例亚临床甲减患儿作为研究对象,根据不同治疗方案将患儿分为对照组和观察组,各49例。两组患儿均采用常规处置方法,在此基础上,对照组患儿给予甲状腺素片治疗,观察组给予左甲状腺素小剂量给药。对比两组患儿的甲状腺功能指标、炎症因子、心肌酶、不良反应情况。结果 治疗前,两组患儿的甲状腺功能指标、炎症因子水平与心肌酶谱指标比较,差异均无统计学意义(P均>0.05)。治疗后,两组患儿的促甲状腺激素水平低于治疗前,游离甲状腺素与游离三碘甲状腺原氨酸均高于治疗前,且观察组促甲状腺激素水平低于对照组,游离甲状腺素与游离三碘甲状腺原氨酸均高于对照组,差异均有统计学意义(P均<0.05)。治疗后,两组患儿的炎症因子水平与心肌酶谱指标均低于治疗前,且观察组的炎症因子、心肌酶谱指标均低于对照组,差异均有统计学意义(P均<0.05)。两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论 小儿亚临床甲减应用左甲状腺素小剂量给药可以增强甲状腺功能,抑制炎症反应,保护心肌功能,具有良好的用药安全性。Objective To study the application effect of low-dose administration of levothyroxine in children with sub-clinical hypothyroidism.Methods A total of 98 children with subclinical hypothyroidism admitted to Jilin City Chil-dren's Hospital from January 2023 to June 2024 were convenient to select as the research subjects.According to dif-ferent treatment regimens,the children were divided into a control group and an observation group,with 49 cases in each group.Both groups of children adopted conventional treatment methods.On this basis,the children in the control group were treated with thyroid tablets,while the children in the observation group were given low-dose levothyroxine.The thyroid function indicators,inflammatory factors,myocardial enzymes and adverse reactions of the two groups of children were compared.Results Before treatment,there were no statistically significant differences in the thyroid function indicators,inflammatory factor levels and myocardial enzyme spectrum indicators between the two groups of children(all P>0.05).After treatment,the levels of thyroid-stimulating hormone in both groups of children were lower than those before treatment,and the free thyroxine and free triiodothyronine were higher than those before treatment.Moreover,the level of thyroid-stimulating hormone in the observation group was lower than that in the control group,and the free thyroxine and free triiodothyronine were higher than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the levels of inflammatory factors and myocardial enzyme spec-trum indicators in both groups of children were lower than those before treatment,and the inflammatory factors and myocardial enzyme spectrum indicators in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).There was no statistically significant difference in the inci-dence of adverse reactions between the two groups of children(P>0.05).Conclusion The l

关 键 词：小儿亚临床甲减 左甲状腺素 小剂量给药 甲状腺功能减退 甲状腺功能指标 

分 类 号：R581[医药卫生—内分泌]