苯巴比妥联合地西泮治疗小儿复杂型高热惊厥的临床效果分析  

Analysis of the Clinical Efficacy of Phenobarbital Combined with Diazepam in the Treatment of Complex Febrile Seizures in Children

作　　者：张家风 许兴祥[1] 何敏[1] ZHANG Jiafeng;XU Xingxiang;HE Min(Department of Pediatrics,Jurong People's Hospital,Jurong,Jiangsu,212400,China)

机构地区：[1]句容市人民医院儿科,江苏句容212400

出　　处：《中外医疗》2025年第6期67-70,共4页China & Foreign Medical Treatment

摘　　要：目的探析地西泮联合苯巴比妥治疗复杂性高热惊厥患儿效果。方法方便选取2022年7月—2024年6月句容市人民医院收治的82例复杂性高热惊厥患儿为研究对象,根据治疗方法差异分为对照组(41例,地西泮注射液治疗)与观察组(41例,对照组基础上联合运用苯巴比妥钠)。对比两组患儿的血清学指标、治疗总有效率、并发症发生率。结果治疗总有效率比较,观察组为97.56%(40/41),低于对照组的80.49%(33/41),差异有统计学意义(χ^(2)=4.493,P<0.05)。治疗7 d后,两组患儿血清学指标中脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)、神经元特异性烯醇化酶(neuron specific enolase,NSE)水平均较治疗前低,且观察组BDNF、NSE水平均低于对照组,差异均有统计学意义(P均<0.05)。观察组患儿的并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论临床治疗复杂性高热惊厥患儿联用地西泮注射液+注射用苯巴比妥钠的效果佳,可提升整体疗效,改善患儿的血清学指标,减少并发症发生。Objective To explore the efficacy of diazepam combined with phenobarbital in the treatment of children with complex febrile convulsions.Methods A total of 82 children with complex febrile convulsions admitted to Jurong People's Hospital from July 2022 to June 2024 were conveniently selected as the research subjects and divided into the control group(41 cases,treated with diazepam injection)and the observation group(41 cases,treated with diazepam injection plus phenobarbital sodium injection).The serum indicators,total effective rate of treatment,and incidence of complications were compared between the two groups.Results The total effective rate of treatment in the observation group was 97.56%(40/41),which was higher than that in the control group[80.49%(33/41)],and the difference was statistically significant(χ²=4.493,P<0.05).After 7 d of treatment,the levels of brain-derived neurotrophic factor(BDNF)and neuron specific enolase(NSE)in the serum of both groups were lower than those before treatment,and the levels of BDNF and NSE in the observation group were lower than those in the control group,and differences were statistically significant(all P<0.05).The incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The combined use of diazepam injection and phenobarbital sodium injection in the clinical treatment of children with complex febrile convulsions has a good effect,which can improve the overall therapeutic effect,improve the serum indicators of children,and reduce the incidence of complications.

关 键 词：地西泮 复杂性高热惊厥 临床效果 苯巴比妥 

分 类 号：R720.5[医药卫生—儿科]