酪酸梭菌二联活菌散在儿童抗生素相关性腹泻中应用的疗效  

Efficacy of Combined Clostridium Butyricum and Bifidobacterium Powder in Children with Antibiotic-associated Diarrhea

作　　者：崔超 崔恒 汪元霞 CUI Chao;CUI Heng;WANG Yuanxia(Department of Paediatrics,Tongren Maternal and Child Health Hospital,Tongren,Guizhou,554300,China)

机构地区：[1]贵州省铜仁市妇幼保健院儿科,贵州铜仁554300

出　　处：《中外医疗》2025年第6期71-75,共5页China & Foreign Medical Treatment

摘　　要：目的探讨酪酸梭菌二联活菌散在儿童抗生素相关性腹泻(antibiotic-associated diarrhoea,AAD)中的治疗效果。方法随机选取2021年11月—2024年5月期间在贵州省铜仁市妇幼保健院就诊的80例AAD患儿作为研究对象,根据不同治疗方法分组,各40例。常规组接受常规处理及蒙脱石散治疗,探究组则在常规组基础上联合酪酸梭菌二联活菌散治疗。对比两组症状消失时间、粪便常规水平、并发症发生率及治疗有效率。结果治疗后,探究组患儿的症状消失时间(腹泻、腹痛、恶心呕吐、口干口渴)短于常规组,差异有统计学意义(P<0.05)。治疗前,两组患儿的粪便常规(白细胞、红细胞、脂肪球)水平比较,差异无统计学意义(P>0.05)。治疗后,两组患儿的粪便常规水平均低于治疗前,且探究组患儿的粪便常规水平低于常规组,差异均有统计学意义(P均<0.05)。探究组患儿并发症发生率为5.00%(2/40),低于常规组的20.00%(8/40),差异有统计学意义(χ^(2)=4.114,P=0.043)。探究组的治疗总有效率为95.00%(38/40),高于常规组的77.50%(31/40),差异有统计学意义(χ^(2)=5.165,P<0.05)。结论酪酸梭菌二联活菌散联合常规处理及蒙脱石散治疗AAD,能够缩短患儿的症状消失时间,优化粪便常规水平,降低并发症发生率,提高治疗有效率。Objective To explore the therapeutic effect of combined clostridium butyricum and bifidobacterium powder in children with antibiotic-associated diarrhea(AAD).Methods A total of 80 children with AAD who visited Tongren Maternal and Child Health Hospital in Guizhou Province from November 2021 to May 2024 were randomly selected as the research objects and grouped according to different treatment methods,with 40 cases in each group.The conventional group received conventional treatment and montmorillonite powder treatment,while the exploration group was treated with combined clostridium butyricum and bifidobacterium powder on the basis of the conventional group.The symptom disappearance time,fecal routine levels,incidence of complications,and treatment efficiency were compared between the two groups.Results After treatment,the symptom disappearance time(diarrhea,abdominal pain,nausea and vomiting,dry mouth and thirst)of the children in the exploration group was shorter than that in the conventional group,and the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in the fecal routine(white blood cells,red blood cells,fat globules)levels between the two groups of children(P>0.05).After treatment,the fecal routine levels of both groups of children were lower than those before treatment,and the fecal routine levels of the children in the exploration group were lower than those in the conventional group,and the differences were statistically significant(all P<0.05).The incidence of complications in the exploration group was 5.00%(2/40),which was lower than that in the conventional group[20.00%(8/40)],and the difference was statistically significant(χ²=4.114,P=0.043).The total treatment efficiency of the exploration group was 95.00%(38/40),which was higher than that in the conventional group[77.50%(31/40)],and the difference was statistically significant(χ²=5.165,P<0.05).Conclusion The combined clostridium butyricum and bifidobacterium powder combined w

关 键 词：酪酸梭菌二联活菌散制剂 儿童 抗生素相关性腹泻 疗效分析 

分 类 号：R725.7[医药卫生—儿科]