妊娠期糖尿病患者肠道菌群联合新生儿免疫功能指标对新生儿发生感染性肺炎的预测价值  

Predictive Value of Intestinal Flora Combined with Neonatal Immune Function Indexes in Neonatal Infectious Pneumonia in Patients with Gestational Diabetes Mellitus

作　　者：任江龙 吕朋举 黄永杰 胡守奎 REN Jianglong;LYU Pengju;HUANG Yongjie(Department of Laboratory Medicine,Zhengzhou University Affiliated Zhengzhou Central Hospital,Zhengzhou Henan 450000)

机构地区：[1]郑州大学附属郑州中心医院检验科,河南郑州450000

出　　处：《医学临床研究》2025年第3期444-446,449,共4页Journal of Clinical Research

摘　　要：【目的】探讨妊娠期糖尿病(GDM)患者肠道菌群联合新生儿免疫功能指标对新生儿发生感染性肺炎的预测价值。【方法】选取2023年8月至2024年10月本院收治的82例孕晚期GDM患者,以新生儿是否发生感染性肺炎分为感染组(n=10)与未感染组(n=72),收集两组一般资料,检测产妇肠道菌群、新生儿免疫指标,采用多因素Logistic回归分析新生儿发生感染性肺炎的危险因素,采用受试者工作特征(ROC)曲线评估产妇肠道菌群联合新生儿免疫指标对新生儿感染性肺炎的预测价值。【结果】感染组Chaol指数、Shannon指数、CD3^(+)、CD4^(+)、CD8^(+)、IgG低于未感染组。多因素分析结果显示:Chaol指数、Shannon指数、IgG较低均是新生儿发生感染性肺炎的危险因素(P<0.05);ROC曲线分析结果显示:产妇肠道菌群联合新生儿免疫指标预测新生儿发生感染性肺炎的敏感度、特异度分别为97.5%、95.5%,ROC曲线下面积为0.987,均优于单项检测。【结论】产妇肠道菌群失调和新生儿免疫功能指标异常是新生儿发生感染性肺炎的危险因素,产妇肠道菌群联合新生儿免疫指标对新生儿发生感染性肺炎具有较高的预测价值。【Objective】To investigate the value of intestinal flora combined with neonatal immune function index in predicting neonatal infectious pneumonia in patients with gestational diabetes mellitus(GDM).【Methods】A total of 82 patients with GDM in late pregnancy admitted to our hospital from August 2023 to October 2024 were divided into infected group(n=10)and uninfected group(n=72)according to whether their newborns developed infectious pneumonia.General data of the two groups were collected,and maternal intestinal flora and neonatal immune indexes were detected.Multivariate logistic regression was used to analyze the risk factors of neonatal infectious pneumonia,and receiver operating characteristic(ROC)curve was used to evaluate the predictive value of maternal intestinal flora combined with neonatal immune indexes for neonatal pneumonia.【Results】The Chaol index,Shannon index,CD3^(+),CD4^(+),CD8^(+)and IgG in the infected group were lower than those in the uninfected group.The results of multi-factor analysis showed that low Chaol index,Shannon index and IgG were risk factors for neonatal infectious pneumonia(P<0.05).ROC curve analysis results showed that the sensitivity and specificity of maternal intestinal flora combined with neonatal immune indexes in predicting neonatal infectious pneumonia were 97.5%and 95.5%,respectively,and the area under ROC curve was 0.987,both of which were better than single detection.【Conclusion】The imbalance of maternal intestinal flora and abnormal neonatal immune function indexes are the risk factors for neonatal infectious pneumonia,and the combination of maternal intestinal flora and neonatal immune indexes has high predictive value for neonatal infectious pneumonia.

关 键 词：糖尿病 妊娠 胃肠道微生物组 婴儿 新生 肺炎 

分 类 号：R714.256[医药卫生—妇产科学]