肺炎支原体肺炎合并胸腔积液患儿血清HMGB1、PTX3水平及其与疾病严重程度和预后的相关性  

Serum HMGB1 and PTX3 Levels and their Correlation with Disease Severity and Prognosis in Children with Mycoplasma Pneumoniae Pneumonia Complicated with Pleural Effusion

作　　者：唐美玲 张海丽 王剑 TANG Meiling;ZHANG Haili;WANG Jian(Nantong Ruici Hospital Affiliated to Yangzhou University,Nantong Jiangsu 226010)

机构地区：[1]扬州大学附属南通瑞慈医院,江苏南通226010

出　　处：《医学临床研究》2025年第3期467-469,473,共4页Journal of Clinical Research

摘　　要：【目的】探讨肺炎支原体肺炎(MPP)合并胸腔积液患儿血清高迁移率族蛋白B1(HMGB1)和正五聚蛋白3(PTX3)水平及其与疾病严重程度和预后的相关性。【方法】选择2020年1月至2023年12月本院收治的88例MPP患儿,根据患儿是否合并胸腔积液将其分为MPP合并胸腔积液组(合并组,n=58)和未合并胸腔积液的MPP患儿(未合并组,n=30)。选择同期来本院进行健康体检的健康儿童作为对照组(n=30)。根据MPP患儿疾病严重程度将合并组患儿进一步分为轻度组(n=23)、中度组(n=18)和重度组(n=17),根据患儿预后情况将合并组分为良好组(n=27)和不良组(n=31)。比较不同疾病严重程度患儿血清HMGB1、PTX3水平,比较不同预后患儿血清HMGB1、PTX3水平,采用Spearman相关系数分析血清HMGB1、PTX3与患儿症状、疾病严重程度、预后的相关性。【结果】未合并组、合并组血清HMGB1、PTX3水平显著高于对照组,且合并组显著高于未合并组,差异有统计学意义(P<0.05)。中度组、重度组血清HMGB1、PTX3水平显著高于轻度组,且重度组显著高于中度组,差异有统计学意义(P<0.05)。良好组患儿血清HMGB1、PTX3水平均低于不良组患儿,差异有统计学意义(P<0.05)。Spearman相关性分析显示,血清HMGB1、PTX3水平与患儿合并胸腔积液情况、疾病严重程度、预后情况呈正相关(P<0.05)。【结论】MPP合并胸腔积液患儿血清HMGB1、PTX3水平升高,其与疾病严重程度和预后显著相关。【Objective】To investigate the serum levels of high mobility group protein B1(HMGB1)and pentaprotein 3(PTX3)and their correlation with disease severity and prognosis in children with mycoplasma pneumoniae pneumonia(MPP)complicated with pleural effusion.【Methods】A total of 88 children with MPP admitted to our hospital from January 2020 to December 2023 were selected and divided into MPP children with pleural effusion group(combined group,n=58)and MPP children without pleural effusion group(uncombined group,n=30)according to whether the children had pleural effusion.Healthy children who came to our hospital for physical examination at the same period were selected as the control group(n=30).According to the severity of MPP,the combined group was further divided into mild group(n=23),moderate group(n=18)and severe group(n=17),and the combined group was divided into good group(n=27)and adverse group(n=31)according to the prognosis of the children.Serum HMGB1 and PTX3 levels in children with different disease severity were compared,and serum HMGB1 and PTX3 levels in children with different prognosis were compared.Spearman correlation coefficient was used to analyze the correlation between serum HMGB1 and PTX3 and symptoms,disease severity and prognosis of children.【Results】The levels of serum HMGB1 and PTX3 in the non-combined group and the combined group were significantly higher than those in the control group,and the levels in the combined group were significantly higher than those in the non-combined group,with statistical significance(P<0.05).Serum HMGB1 and PTX3 levels in the moderate group and the severe group were significantly higher than those in the mild group,and the severe group was significantly higher than the moderate group,with statistical significance(P<0.05).The levels of serum HMGB1 and PTX3 in the good group were lower than those in the bad group,and the difference was statistically significant(P<0.05).Spearman correlation analysis showed that serum HMGB1 and PTX3 levels were positively

关 键 词：肺炎 支原体 胸腔积液 高迁移率族蛋白质类 多聚蛋白质类 

分 类 号：R725.631[医药卫生—儿科]