《重订古今名医临证金鉴·腹泻便秘卷》治疗便秘用药规律研究  

Study on Medication Rules for Treating Constipation in Revised Ancient and Modern Famous Doctors Clinical Evidence:Diarrhea and Constipation Volume

作　　者：钱诗维 梁彪 杨忆衡 倪嘉淳 黄硕 王振宜[1] QIAN Shiwei;LIANG Biao;YANG Yiheng;NI Jiachun;HUANG Shuo;WANG Zhenyi(Department of Anorectal Surgery,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院肛肠科,上海200437

出　　处：《新中医》2025年第7期1-6,共6页New Chinese Medicine

基　　金：国家自然科学基金面上项目(82274531,81973859);上海市卫生健康委员会卫生行业临床研究专项面上项目(202140185)。

摘　　要：目的:基于数据挖掘技术总结古今名医治疗便秘用药规律,为临床治疗便秘提供参考。方法:整理《重订古今名医临证金鉴·腹泻便秘卷》历代医家治疗便秘的有效经验方,采用Excel 2019建立处方用药数据库。采用古今医案云平台(V2.3.8)、VOSviewer、Cytoscape3.9.0软件进行用药频次分析、药物属性分析、关联规则分析、聚类分析、复杂网络分析,研究治疗便秘的用药规律。结果:共纳入191首处方,涉及中药208味,用药频次1565次,高频药物主要有当归、火麻仁、大黄、肉苁蓉、陈皮、甘草、生地黄等。药性以温、寒、平为主;药味以甘、苦、辛为主;归经主要以五脏、胃经、大肠经为主。高频药物功效类别主要有补虚药(26.26%)、理气药(12.72%)、清热药(11.31%)、泻下药(11.05%)、化痰止咳平喘药(8.56%)等。聚类分析表明高频药物可聚为5类。关联规则分析提示厚朴-大黄、郁李仁-肉苁蓉、肉苁蓉-当归等为常用药对。结论:《重订古今名医临证金鉴·腹泻便秘卷》历代医家治疗便秘用药以温肾益精、健脾理气、润肠通便为主,可为临床遣方用药提供依据。Objective:To summarize the medication rules for treating constipation by famous doctors throughout history based on data mining technology and provide a reference for clinical treatment of constipation.Methods:Effective experienced prescriptions for treating constipation by famous doctors throughout history in Revised Ancient and Modern Famous Doctors Clinical Evidence:Diarrhea and Constipation Volume were collected and a prescription medication database was established via Excel 2019.The Ancient and Modern Medical Case Cloud Platform(V2.3.8),VOSviewer,Cytoscape 3.9.0 software were used for medication frequency analysis,medicinal property analysis,association rule analysis,cluster analysis,and complex network analysis to study the medication rules for treating constipation.Results:A total of 191 prescriptions involving 208 Chinese medicinals with 1565 medication frequencies were included.The high-frequency Chinese medicinals mainly included Angelicae Sinensis Radix,Cannabis Fructus,Rhei Radix et Rhizoma,Cistanches Herba,Citri Reticulatae Pericarpium,Glycyrrhizae Radix et Rhizoma and Rehmanniae Radix.The medicinal properties were mainly warm,cold,and neutral;the medicinal flavors were mainly sweet,bitter,and acrid;and the channel entries were mainly related to the five zang-organs,stomach channel,and large intestine channel.The high-frequency Chinese medicinals were mainly categorized into deficiency-supplementing medicinals(26.26%),qi-rectifying medicinals(12.72%),heat-clearing medicinals(11.31%),purgative medicinals(11.05%),and medicinals for dissolving phlegm,easing cough,and relieving panting(8.56%).Cluster analysis showed that high-frequency Chinese medicinals could be clustered into five categories.Association rule analysis suggested that Magnoliae Officinalis Cortex-Rhei Radix et Rhizoma,Pruni Semen-Cistanches Herba and Cistanches Herba-Angelicae Sinensis Radix were commonly used medicinal pairs.Conclusion:The Chinese medicinals used by famous doctors throughout history in Revised Ancient and Modern Famous

关 键 词：《重订古今名医临证金鉴·腹泻便秘卷》 便秘 数据挖掘 用药规律 

分 类 号：R256.35[医药卫生—中医内科学]