芍药甘草汤穴位贴敷联合腺苷钴胺治疗阴虚血瘀型糖尿病周围神经病变临床研究  

Clinical Study on Acupoint Application of Shaoyao Gancao Decoction Combined with Adenosylcobalamin for Diabetic Peripheral Neuropathy of Yin Deficiency and Blood Stasis Type

作　　者：阮佳佳[1] 朱梦雅 RUAN Jiajia;ZHU Mengya(Department of Neurology,Taizhou Integrated Chinese and Western Medicine Hospital,Taizhou Zhejiang 318000,China)

机构地区：[1]台州市中西医结合医院神经内科,浙江台州318000

出　　处：《新中医》2025年第7期56-60,共5页New Chinese Medicine

基　　金：温岭市社会发展科技项目(2023S00181)。

摘　　要：目的:观察芍药甘草汤穴位贴敷联合腺苷钴胺治疗阴虚血瘀型糖尿病周围神经病变(DPN)对患者血液流变学及周围神经传导速度的影响。方法:选取2021年11月—2023年11月台州市中西医结合医院收治的82例阴虚血瘀型DPN患者,采用随机数字表法分为观察组及对照组各41例。观察组接受芍药甘草汤穴位贴敷联合腺苷钴胺肌肉注射治疗,对照组接受腺苷钴胺肌肉注射治疗。比较2组治疗前后中医证候积分,血液流变学(全血高切黏度、纤维蛋白原、血细胞比容和血小板黏附率)指标及周围神经传导速度[正中和腓神经感觉神经传导速度(SNCV)和运动神经传导速度(MNCV)],比较2组不良反应发生率。结果:治疗后,2组肢体麻木、腿足挛急、腰膝酸软、五心烦热、失眠梦多等中医证候积分均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后,2组全血高切黏度、纤维蛋白原、血细胞比容和血小板黏附率均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后,2组正中神经和腓神经SNCV、MNCV均加快(P<0.05),且观察组快于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:芍药甘草汤穴位贴敷联合腺苷钴胺肌肉注射有利于改善阴虚血瘀型DPN患者手足畏寒等中医症状,改善血液流变学,增强周围神经传导速度。Objective:To observe the effects of acupoint application of Shaoyao Gancao Decoction combined with adenosylcobalamin on hemorheology and peripheral nerve conduction velocity in patients with diabetic peripheral neuropathy(DPN)of yin deficiency and blood stasis type.Methods:A total of 82 patients with DPN of yin deficiency and blood stasis type admitted to the Taizhou Integrated Chinese and Western Medicine Hospital from November 2021 to November 2023 were enrolled and randomly divided into the observation group and the control group by random number table method,with 41 patients in each group.The observation group received acupoint application of Shaoyao Gancao Decoction combined with intramuscular injection of adenosylcobalamin,while the control group received intramuscular injection of adenosylcobalamin alone.The scores of traditional Chinese medicine syndromes,hemorheological indicators(including whole blood high-shear viscosity,fibrinogen,hematocrit,and platelet adhesion rate),and peripheral nerve conduction velocities[sensory nerve conduction velocity(SNCV)and motor nerve conduction velocity(MNCV)of the median and peroneal nerves]before and after treatment were compared between the two groups.The incidence of adverse reactions was also compared.Results:After treatment,the scores of traditional Chinese medicine syndromes such as limb numbness,leg and foot cramps,soreness and weakness of the waist and knees,vexing heat in the five sensation centers,and insomnia with profuse dreaming were decreased in both groups(P<0.05),and the scores in the observation group were lower than those in the control group(P<0.05).After treatment,the whole blood high-shear viscosity,fibrinogen,hematocrit,and platelet adhesion rate were decreased in both groups(P<0.05),and the values in the observation group were lower than those in the control group(P<0.05).After treatment,the SNCV and MNCV of the median and peroneal nerves were increased in both groups(P<0.05),and the values in the observation group were higher than those in the c

关 键 词：糖尿病周围神经病变 芍药甘草汤 穴位贴敷 腺苷钴胺 血液流变学 周围神经传导速度 

分 类 号：R587.2[医药卫生—内分泌]