防风通圣散加减治疗老年高血压患者功能性便秘临床研究  

Clinical Study on Modified Fangfeng Tongsheng Powder for Functional Constipation of Patients with Elderly Hypertension

作　　者：武倩喻 潘铨[2] 郑勇飞[3] WU Qianyu;PAN Quan;ZHENG Yongfei(Department of Internal Medicine,Medical Examination Center,Lishui Hospital of Traditional Chinese Medicine,Lishui Zhejiang 323000,China;Department of Chinese Medicine Cardiology,Lishui Hospital of Traditional Chinese Medicine,Lishui Zhejiang 323000,China;Department of Chinese Medicine,Lishui Hospital of Traditional Chinese Medicine,Lishui Zhejiang 323000,China)

机构地区：[1]丽水市中医院体检中心内科,浙江丽水323000 [2]丽水市中医院中医心内科,浙江丽水323000 [3]丽水市中医院中医科,浙江丽水323000

出　　处：《新中医》2025年第7期66-70,共5页New Chinese Medicine

摘　　要：目的:观察防风通圣散加减治疗老年高血压患者功能性便秘的临床疗效。方法:选择2021年1月—2022年12月丽水市中医院收治的76例老年高血压功能性便秘患者,按照随机数字表法分为观察组和对照组各38例。对照组使用常规治疗,观察组在对照组基础上联合防风通圣散加减方治疗,2组均持续治疗4周。比较2组临床疗效及不良反应发生率,比较2组治疗前后血清胃动素(MTL)、血管活性肠肽(VIP)水平、72 h标记物排出率、便秘严重度评分量表(CSS)及便秘患者生活质量自评量表(PAC-QOL)评分。结果:观察组西医疗效总有效率89.47%(34/38),高于对照组68.42%(26/38)(P<0.05)。观察组中医疗效总有效率92.11%(35/38),高于对照组71.05%(27/38)(P<0.05)。治疗后,2组血清MTL、VIP水平均升高(P<0.05),且观察组高于对照组(P<0.05)。治疗后,2组72 h标记物排出率均升高(P<0.05),且观察组高于对照组(P<0.05);2组CSS评分、PAC-QOL评分均降低(P<0.05),且观察组低于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:防风通圣散加减治疗老年高血压患者功能性便秘疗效明显,有助于改善患者症状及生活质量。Objective:To observe the clinical effect of modified Fangfeng Tongsheng Powder in the treatment of functional constipation of patients with elderly hypertension.Methods:A total of 76 elderly patients with hypertension and functional constipation admitted to Lishui Hospital of Traditional Chinese Medicine from January 2021 to December 2022 were selected and divided into an observation group and a control group,with 38 cases in each group,according to the random number table method.The control group received conventional treatment,and the observation group was treated with the modified Fangfeng Tongsheng Powder in addition to the treatment in the control group.Both groups were treated for four weeks.The clinical effects and the incidence of adverse reactions were compared between the two groups.The levels of serum motilin(MTL)and vasoactive intestinal peptide(VIP),the 72-hour marker expulsion rate,and the scores of Constipation Severity Score(CSS)and the Patient Assessment of Constipation Quality of Life(PAC-QOL)were compared before and after treatment in both groups.Results:The total effective rate of western medical treatment in the observation group was 89.47%(34/38),which was higher than that of 68.42%(26/38)in the control group(P<0.05).The total effective rate of Chinese medical treatment in the observation group was 92.11%(35/38),which was higher than that of 71.05%(27/38)in the control group(P<0.05).After treatment,the levels of serum MTL and VIP in both groups were increased(P<0.05),and the levels in the observation group were higher than those in the control group(P<0.05).After treatment,the 72-hour marker expulsion rates in both groups were increased(P<0.05),and the rate in the observation group was higher than that in the control group(P<0.05);the CSS and PAC-QOL scores in both groups were decreased(P<0.05),and the observation group had lower scores than the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The modifi

关 键 词：高血压 功能性便秘 防风通圣散 老年 生活质量 血清胃动素 血管活性肠肽 

分 类 号：R259[医药卫生—中西医结合]