温通方对哺乳期乳腺炎乳房微生态的调节作用机制研究  

Study on the Mechanism of Wentong Prescription in Regulating Breast Microecology in Lactational Mastitis

作　　者：李超男 兰菲 吴一镭 徐超 LI Chaonan;LAN Fei;WU Yilei;XU Chao(Department of Surgery,Hangzhou Linping Hospital of Integrated Traditional Chinese and Western Medicine,Hangzhou Zhejiang 330113,China)

机构地区：[1]杭州市临平区中西医结合医院外科,浙江杭州330113

出　　处：《新中医》2025年第7期125-129,共5页New Chinese Medicine

基　　金：杭州市医药卫生科技项目(B20220506)。

摘　　要：目的:分析温通方对哺乳期乳腺炎乳房微生态的调节作用机制。方法:选取2022年1月—2023年10月杭州市临平区中西医结合医院收治的68例哺乳期乳腺炎患者,按自身前后对照试验,均采用温通方治疗。评估治疗效果,检测治疗前后乳汁、粪便菌群相对丰度及多样性,分析温通方对哺乳期乳腺炎乳房微生态的调节作用。结果:治疗后,患者乳汁双歧杆菌、乳酸菌、操作分类单元数目、Faith谱系多样性指数、Shannon指数、Chaol指数水平均较治疗前升高(P<0.05),金黄色葡萄球菌、肠球菌水平均较治疗前下降(P<0.05)。治疗后,患者粪便双歧杆菌、乳酸菌、操作分类单元数目、Faith谱系多样性指数、Shannon指数、Chaol指数水平均较治疗前升高(P<0.05),金黄色葡萄球菌、肠球菌水平均较治疗前下降(P<0.05)。治愈患者乳汁双歧杆菌、乳酸菌、操作分类单元数目、Faith谱系多样性指数、Shannon指数、Chaol指数水平较未治愈患者高(P<0.05),金黄色葡萄球菌、肠球菌水平较未治愈患者低(P<0.05)。治愈患者粪便双歧杆菌、乳酸菌、操作分类单元数目、Faith谱系多样性指数、Shannon指数、Chaol指数水平较未治愈患者高(P<0.05),金黄色葡萄球菌、肠球菌水平较未治愈患者低(P<0.05)。乳汁及粪便双歧杆菌、乳酸菌、金黄色葡萄球菌、肠球菌、操作分类单元数目、Faith谱系多样性指数、Shannon指数、Chaol指数均呈正相关(r=0.526、0.514、0.601、0.417、0.589、0.601、0.588、0.572,均P<0.05)。治疗后,乳汁、粪便双歧杆菌、乳酸菌、操作分类单元数目、Faith谱系多样性指数、Shannon指数、Chaol指数水平与痊愈率呈正相关,乳汁、粪便金黄色葡萄球菌、肠球菌水平与痊愈率呈负相关(P<0.05)。结论:温通方治疗哺乳期乳腺炎微生态紊乱情况能得到调节,双歧杆菌、乳酸菌水平上升,金黄色葡萄球菌、肠球菌水平降低,且患者微生态Objective:To analyze the regulatory mechanism of Wentong Prescription on breast microecology in lactational mastitis.Methods:A total of 68 patients with lactational mastitis admitted to Hangzhou Linping Hospital of Integrated Traditional Chinese and Western Medicine from January 2022 to October 2023 were enrolled.A selfcontrolled before-and-after trial was conducted,and all patients were treated with Wentong Prescription.The therapeutic effects were evaluated,and the relative abundance and diversity of breast milk and fecal flora before and after treatment were detected to analyze the regulatory effect of Wentong Prescription on breast microecology in lactational mastitis.Results:After treatment,the levels of Bifidobacterium,Lactic Acid Bacteria,operational taxonomic units(OTUs),Faith's phylogenetic diversity index,Shannon's index,and Chao1 index in breast milk were increased when compared with those before treatment(P<0.05),while the levels of Staphylococcus Aureus and Enterococci were decreased(P<0.05).After treatment,the levels of Bifidobacterium,Lactic Acid Bacteria,OTUs,Faith's phylogenetic diversity index,Shannon's index,and Chao1 index in feces of patients were also increased when compared with those before treatment(P<0.05),while the levels of Staphylococcus Aureus and Enterococci were decreased(P<0.05).Compared with non-cured patients,cured patients had higher levels of Bifidobacterium,Lactic Acid Bacteria,OTUs,Faith's phylogenetic diversity index,Shannon's index,and Chao1 index in breast milk(P<0.05)and lower levels of Staphylococcus Aureus and Enterococci(P<0.05).After treatment,the levels of Bifidobacterium,Lactic Acid Bacteria,OTUs,Faith's phylogenetic diversity index,Shannon's index,and Chao1 index in feces of cured patients were higher than those of non-cured patients(P<0.05),while the levels of Staphylococcus Aureus and Enterococci were lower(P<0.05).There were positive correlations between Bifidobacterium,Lactic Acid Bacteria,Staphylococcus Aureus,Enterococci,OTUs,Faith's phylogenetic diversity i

关 键 词：哺乳期 乳腺炎 温通方 乳房微生态 粪便 

分 类 号：R655.8[医药卫生—外科学]