旋转式血泵溶血的研究进展  

Research progress on hemolysis of rotary blood pump

作　　者：荆腾[1] 程佳楠 孙浩然 潘爱娣 JING Teng;CHENG Jianan;SUN Haoran;PAN Aidi(National Research Center of Pumps,Jiangsu University,Zhenjiang,212013,Jiangsu,P.R.China)

机构地区：[1]江苏大学国家水泵及系统工程技术研究中心,江苏镇江212013

出　　处：《中国胸心血管外科临床杂志》2025年第4期560-566,共7页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：国家自然科学基金资助项目(31600794);江苏大学高级人才专业研究基金项目(12JDG046)。

摘　　要：溶血是血泵心室辅助装置使用的主要并发症之一。溶血产生的主要影响因素包括红细胞所承受的剪切应力和暴露时间。此外,局部负压、温度等因素也可能对溶血产生影响。溶血预测模型及其经验常数的不同组合对预测结果产生了显著差异;与幂律模型相比,OPO模型能够更好地考虑湍流的复杂性。在改善溶血性能方面,研究主要集中于血泵结构的优化,如泵间隙、叶轮、导叶等设计的调整。少部分学者通过血泵转速控制模式及血液相容性材料的选择,对血泵的溶血性能进行了研究。本文针对目前应用最广泛的旋转式血泵,综述了溶血产生的主要影响因素、溶血性能的预测和改善方法,探讨了当前溶血研究中存在的局限性,并对未来的研究方向进行了展望。Hemolysis is one of the main complications associated with the use of ventricular assist devices.The primary factors influencing hemolysis include the shear stress and exposure time experienced by red blood cells.In addition,factors such as local negative pressure and temperature may also impact hemolysis.The different combinations of hemolysis prediction models and their empirical constants lead to significant variations in prediction results;compared to the power-law model,the OPO model better accounts for the complexity of turbulence.In terms of improving hemolytic performance,research has primarily focused on optimizing blood pump structures,such as adjustments to pump gaps,impellers,and guide vanes.A small number of scholars have studied hemolytic performance through control modes of blood pump speed and the selection of blood-compatible materials.This paper reviews the main factors influencing hemolysis,prediction methods,and improvement strategies for rotary blood pumps,which are currently the most widely used.It also discusses the limitations in current hemolysis research and provides an outlook on future research directions.

关 键 词：旋转式血泵 溶血 剪切应力 结构优化 综述 

分 类 号：R318.1[医药卫生—生物医学工程]