新型X-Clip经导管缘对缘修复系统应用于功能性重度二尖瓣反流患者首例报告  

Novel X-Clip transcatheter edge-to-edge repair system for treating severe functional mitral regurgitation:The first case report

作　　者：戴佳祁 朱达 王首正 潘湘斌[1,2] DAI Jiaqi;ZHU Da;WANG Shouzheng;PAN Xiangbin(Department of Structural Heart Center,Fuwai Yunnan Hospital,Chinese Academy of Medical Sciences,Affiliated Cardiovascular Hospital of Kunming Medical University,Kunming,650102,P.R.China;Department of Structural Heart Disease,National Center for Cardiovascular Disease,Fuwai Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing,100037,P.R.China)

机构地区：[1]云南省阜外心血管病医院,昆明医科大学附属心血管医院结构性心脏病中心,昆明650102 [2]中国医学科学院,北京协和医学院,国家心血管病中心,阜外医院结构性心脏病中心,北京100037

出　　处：《中国胸心血管外科临床杂志》2025年第4期567-570,共4页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：“十四五”重点研发计划(2022YFC2503400);云南省科技重大专项(202302AA310045)。

摘　　要：对于经优化药物和器械治疗仍有心力衰竭症状的中重度功能性二尖瓣反流(functional mitral regurgitation,FMR)患者,经导管二尖瓣缘对缘修复术(transcatheter mitral valve edge-to-edge repair,TEER)逐渐成为可靠的治疗方案。随着TEER相关器械的不断研发和改进,我国目前已有数十款自主研发的TEER器械正在进行临床试验。在本研究中,我们报道了第1例X-Clip®TEER装置治疗重度FMR患者的病例。该患者为60岁男性,因扩张型心肌病导致FMR。术前经胸超声心动图提示二尖瓣大量反流(4+),术中应用X-Clip®系统对患者行经皮修复术,术后即刻超声提示二尖瓣反流减少至微量。术后1个月随访时患者症状、纽约心脏协会(NYHA)心功能分级等均得到改善,经胸超声心动图复查显示二尖瓣微量反流(1+)。For patients with moderate-to-severe functional mitral regurgitation(FMR)who continue to experience heart failure symptoms despite optimized medical and device therapy,transcatheter mitral valve edge-to-edge repair(TEER)is increasingly becoming a reliable treatment option.With the continuous research and development and improvement of TEER-related devices,there are currently dozens of domestically developed TEER devices undergoing clinical trials in China.In this study,we report the first case of a patient with severe FMR treated with the X-Clip®TEER system.The patient,a 60-year-old male,suffered FMR attributed to dilated cardiomyopathy.Preoperative transthoracic echocardiography showed severe mitral regurgitation(4+).He underwent percutaneous repair using the X-Clip®system,and immediate postoperative ultrasound showed mild mitral regurgitation.At the 1-month follow-up,the patient’s symptoms and New York Heart Association(NYHA)functional class improved,and a follow-up transthoracic echocardiogram showed mild mitral regurgitation(1+).

关 键 词：二尖瓣 功能性反流 经导管二尖瓣缘对缘修复术 国产器械 病例报告 

分 类 号：R654.2[医药卫生—外科学]