肺力咳联合盐酸氨溴索对儿童支原体肺炎患者的免疫调节炎症因子及氧化应激水平的影响  

Effect of pulmonary cough combined with ambroxol hydrochloride on immune regulation,inflammatory factors,and oxidative stress levels in children with Mycoplasma pneumonia

作　　者：袁灵皓 王咪露 徐瑾姣 Yuan Linghao;Wang Milu;Xu Jinjiao(Department of Pediatrics,Ninth People′s Hospital of Hangzhou,Hangzhou,Zhejiang 311200,China)

机构地区：[1]杭州市第九人民医院儿科,浙江杭州311200

出　　处：《中国药物与临床》2025年第5期300-304,共5页Chinese Remedies & Clinics

摘　　要：目的研究肺力咳联合盐酸氨溴索对儿童支原体肺炎(MPP)患者的免疫调节、炎症因子及氧化应激水平的影响。方法回顾性分析2023年1月至2024年3月在浙江省杭州市第九人民医院诊治的MPP患儿200例,按照不同的治疗方法分为氨溴索组(100例,盐酸氨溴索治疗)和联合组(100例,肺力咳联合盐酸氨溴索治疗),比较2组免疫功能指标、炎症因子、氧化应激指标。结果和治疗前相比,2组治疗7 d后免疫球蛋白A(IgA)、G(IgG)、M(IgM)升高(P<0.05),且联合组治疗7 d后IgA(2.96±0.27和2.59±0.27)g/L、IgG(13.10±1.05和12.61±1.14)g/L、IgM(1.83±0.23和1.60±0.25)g/L和氨溴索组相比更高(t=9.645、3.160、6.835,P均<0.05)。和治疗前相比,2组治疗7 d后白细胞介素(IL)-6、IL-10、C反应蛋白(CRP)、肿瘤坏死因子(TNF)-α降低(P<0.05),且联合组治疗7 d后IL-6(40±10和54±10)pg/ml、IL-10(30±5和44±5)pg/ml、CRP(12.3±1.4和20.1±2.0)mg/L、TNF-α(10±3和16±4)pg/ml和氨溴索组相比更低(t=10.426、21.227、31.659、11.143,P均<0.05)。和治疗前相比,2组治疗7d后丙二醛(MDA)降低(P<0.05),2组治疗7 d后胱甘肽过氧化物酶(GSH-PX)、超氧化物歧化酶(SOD)升高(P<0.05),且联合组治疗7 d后MDA(3.4±1.0和5.1±1.5)nmol/ml和氨溴索组相比更低(t=9.549,P<0.05),联合组治疗7 d后GSH-PX(49±8和44±8)U/L、SOD(81±9和74±9)U/ml与氨溴索组相比更高(t=4.653、5.451,P均<0.05)。联合组临床总有效率为93.0%,与氨溴索组的82.0%相比更高(χ2=5.531,P<0.05)。结论肺力咳联合盐酸氨溴索应用于儿童MPP患儿的治疗中,可调节免疫,降低炎症因子,减轻氧化应激,提升治疗效果。Objective To study the effects of pulmonary cough combined with ambroxol hydrochloride on immune regulation,inflammatory factors,and oxidative stress levels in children with Mycoplasma pneumonia(MPP).Methods A total of 200 children with MPP treated at our hospital from January 2023 to March 2024 were divided into an ambroxol group(100 cases,treated with ambroxol hydrochloride)and a combined group(100 cases,treated with pulmonary cough combined with ambroxol hydrochloride)based on differen treatment methods.The immune function indicators,inflammatory factors,and oxidative stress indicators of the two groups were com-pared.Results Compared with before treatment,the levels of immunoglobulin A,G,and M(IgA,IgG,IgM)in-creased in both groups after 7 days of treatment(P<0.05),and the combination group had higher levels of IgA(2.96±0.27 vs 2.59±0.27)g/L,IgG(13.10±1.05 vs 12.61±1.14)g/L,and IgM(1.83±0.23 vs 1.60±0.25)g/L com-pared to the ambroxol group(t=9.645,3.160,6.835,P<0.05).Compared with before treatment,,the levels of in-terleukin-6(IL),IL-10,C-reactive protein(CRP),and tumor necrosis factor(TNF)-αdecreased in both groups after 7 days of treatment(P<0.05),and the combination group showed lower levels of IL-6(40±10 vs 54±10)pg/ml,IL-10(30±5 vs 44±5)pg/ml,CRP(12.3±1.4 vs 20.1±2.0)mg/L,and TNF-α(10±3 vs 16±4)pg/ml compared to the ambroxol group(t=10.426,21.227,31.659,11.143,P<0.05).Compared with before treatment,the levels of malon-dialdehyde(MDA)decreased,while the levels of glutathione peroxidase(GSH-PX)and superoxide dismutase(SOD)increased in both groups after 7 days of treatment(P<0.05).Moreover,the combined group had significantly lower MDA levels(3.4±1.0 vs 5.1±1.5 nmol/ml)and higher GSH-PX(49±8 vs 44±8 U/L)and SOD(81±9 vs 74±9 U/ml)levels compared to the ambroxol group after 7 days of treatment(t=9.549,4.653,5.451;P<0.05).The total clinical effective rate of the combination group was 93.0%,which was higher than the 82.0%of the ambroxol group(χ2=5.531,P<0.05).Conclusion The application of

关 键 词：肺力咳 盐酸氨溴索 肺炎 支原体 免疫调节 炎症因子 氧化应激 

分 类 号：R725.6[医药卫生—儿科]