胰激肽原酶肠溶片联合硫辛酸治疗糖尿病周围神经病变的效果  

Effect of pancreatic kininogenase combined with lipoic acid on diabetic peripheral neuropathy

作　　者：郭要敏 梁拓 Guo Yaomin;Liang Tuo(Department of Pharmacy,Henan Province Hospital of TCM,Zhengzhou,Henan 450000,China)

机构地区：[1]河南省中医院药学部,河南郑州450000

出　　处：《中国药物与临床》2025年第5期305-308,共4页Chinese Remedies & Clinics

摘　　要：目的探究对糖尿病周围神经病变进行硫辛酸联合胰激肽原酶肠溶片治疗对神经传导速度、炎症因子变化的影响。方法按照治疗方法的不同将河南省中医院2022年7月至2024年2月就诊的116例糖尿病周围神经病变患者分为2组,各58例。对照组采取硫辛酸治疗,观察组采取胰激肽原酶联合硫辛酸治疗,对比2组效果,治疗前后采用肌电图仪检测神经传导速度、采用酶联免疫吸附试验检测降钙素原(PCT)、C-反应蛋白(CRP)、白细胞介素-6(IL-6),采用多伦多临床评分系统(TCSS)、密歇根糖尿病神经病变评分(MDNS)评估病情及采用血糖仪检测空腹血糖。结果观察组总有效率高于对照组(χ^(2)=4.921,P<0.05)。观察组治疗后感觉、运动神经传导速度比对照组快(t=4.367、6.412、3.281、3.595,P均<0.05),PCT、CRP、IL-6水平、TCSS、MDNS评分及空腹血糖比对照组低(t=5.312、13.093、11.907,15.240、9.684、13.282,P均<0.01)。结论胰激肽原酶肠溶片联合硫辛酸治疗糖尿病周围神经病变可提高疗效与神经传导速度,降低炎症水平,改善病情。Objective To investigate the effects of lipoic acid combined with pancreatic kininogenase therapy on nerve conduction velocity and inflammatory factors in patients with diabetic peripheral neuropathy.Methods According to the different treatment methods,a total of 116 hospitalized patients with diabetic periph-eral neuropathy in Henan Province Hospital of TCM from July 2022 to February 2024 were divided into a control group and an observation group(58 cases in each group).The control group was treated with lipoic acid,and the observation group was treated with pancreatic kininogenase combined with lipoic acid.The effects of the two groups were compared.Before and after the treatment,nerve conduction velocity was measured by electromyogra-phy,procalcitonin(PCT).C-reactive protein(CRP)and interleukin-6(IL-6)were measured by enzyme-linked im-munosorbent assays.Disease severity was evaluated by Toronto Clinical Scoring System(TCSS)and Michigan Dia-betic Neuropathy Score(MDNS).Fasting blood glucose levels were measured by glucometer.Statistical analyses were conducted with SPSS 26.0 software.Results The total effective rate of the observation group was signifi-cantly higher than that of the control group(χ^(2)=4.921,P<0.05).After treatment,the sensory and motor nerve con-duction velocity in the observation group were significantly faster than those in the control group(t=4.367,6.412,3.281,3.595,all P<0.05).Additionally,the levels of PCT,CRP,IL-6,TCSS,MDNS scores and fasting blood glu-cose were significantly lower than those in the control group(t=5.312,13.093,11.907,15.240,9.684,13.282,all P<0.01).Conclusion The combination of pancreatic kininogenase and lipoic acid in the treatment of diabetic peripheral neuropathy can improve the therapeutic effect and nerve conduction speed,reduce inflammatory mark-ers,and alleviate disease severity.

关 键 词：糖尿病周围神经病变 胰激肽原酶 硫辛酸 神经传导速度 炎症因子 

分 类 号：R587.2[医药卫生—内分泌]