Toll样受体介导的宿主免疫应答在棘球蚴病中的研究进展  

Research progress on Toll‑like receptors‑mediated host immune responses in echinococcosis

作　　者：周檀芳 朱江 徐心路 祖力皮喀尔·图孙尼亚孜 卡力比夏提·艾木拉江 温浩 ZHOU Tanfang;ZHU Jiang;XU Xinlu;ZULIPIKAER Tuersunniyazi;KALIBIXIATI Aimulajiang;WEN Hao(State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,Clinical Medicine Institute,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,Xinjiang,China)

机构地区：[1]省部共建中亚高发病成因与防治国家重点实验室,新疆医科大学第一附属医院,临床医学研究院,新疆乌鲁木齐830000

出　　处：《中国寄生虫学与寄生虫病杂志》2025年第1期124-128,共5页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：天山英才项目(2023TSYCQNTJ0045);新疆维吾尔自治区重点研发项目(2022B03013-3)。

摘　　要：棘球蚴病是由棘球绦虫幼虫感染引起的人兽共患寄生虫病。棘球蚴感染能够调节宿主的免疫应答,并改变宿主的免疫微环境,从而引发免疫和炎症反应。Toll样受体(TLR)作为一类模式识别受体,能够有效识别病原体相关分子模式。通过调控TLR表达与功能,可激活下游信号传导途径,这在棘球蚴病的宿主免疫应答中起重要作用。本文综述了TLR尤其是TLR2和TLR4在棘球蚴病研究中的最新进展,并探讨其在未来治疗中的潜在应用,旨在为棘球蚴病的预防和治疗提供新的思路。Echinococcosis is a zoonotic parasitic disease caused by the larval stage of Echinococcus species.Echinococcus infection may modulate host immune response and alter host immune microenvironments,thereby trigger-ing immune and inflammatory responses.As a pattern recognition receptor,Toll-like receptors(TLRs)may effectively recognize pathogen-associated molecular patterns and activate downstream signaling pathways by regulating TLR expres-sion and functions,which play an important role in host immune responses to echinococcosis.This review summarizes the latest progress of TLRs in echinococcosis research,with a special emphasis on TLR2 and TLR4,and discusses their potential applications in future treatments of echinococcosis,so as to provide new insights into for echinococcosis prevention and treatment.

关 键 词：肝棘球蚴病 TOLL样受体 TOLL样受体2 Toll样受体4 免疫 

分 类 号：R532.32[医药卫生—内科学]