Genome-wide association study identifies novel loci associated with feed efficiency traits in Hu lambs  

作　　者：Deyin Zhang Xiaolong Li Fadi Li Xiaoxue Zhang Yuan Zhao Yukun Zhang Zongwu Ma Huibin Tian Xiuxiu Weng Weimin Wang 

机构地区：[1]State Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems,Key Laboratory of Grassland Livestock Industry Innovation,Ministry of Agriculture and Rural Affairs/Engineering Research Center of Grassland Industry,Ministry of Education/College of Pastoral Agriculture Science and Technology,Lanzhou University,Lanzhou 730020,China [2]College of Animal Science and Technology,Gansu Agricultural University,Lanzhou 730070,China

出　　处：《Journal of Integrative Agriculture》2025年第4期1259-1269,共11页农业科学学报(英文版)

基　　金：supported by the National Key R&D Program of China(2021YFD1300901);the National Key R&D Young Scientists Project of China(2022YFD1302000);the Education Department of Gansu Province:Outstanding Postgraduate“Innovation Star”,China(2022CXZX-086);the Major Science and Technology Project of Gansu Province,China(22ZD6NC069)。

摘　　要：Feed efficiency(FE)is a crucial economic trait that significantly impacts profitability in intensive sheep production,and can be evaluated by the residual feed intake(RFI)and feed conversion ratio(FCR).However,the underlying genetic mechanisms that underlie FE-related traits in sheep are not fully understood.Herein,we measured the FE-related traits of 1,280 Hu sheep and conducted the phenotype statistics and correlation analysis,the result showcase that there was a large variation for FE-related traits,and RFI was significant positive correlation with average daily feed intake(ADFI)and FCR.Moreover,a genome-wide association study(GWAS)was conducted using whole-genome resequencing data to investigate the genetic associations of ADFI,FCR and RFI.For ADFI and FCR traits,2 and one single nucleotide polymorphisms(SNPs)exceeded the genome-wide significance threshold,whereas ten and 5 SNPs exceeded the suggestive significance threshold.For RFI traits,only 4 SNPs exceeded the suggestive significance threshold.Finally,a total of 8 genes(LOC101121953,LOC101110202,CTNNA3,IZUMO3,PPM1E,YIPF7,ZSCAN12and LOC105603808)were identified as potential candidate genes for FE-related traits.Simultaneously,we further analyzed the effects of 2 candidate SNPs associated with RFI on growth and FE traits in enlarged experimental population,the results demonstrated that these 2 SNPs was not significantly associated with growth traits(P>0.05),but significantly related to RFI traits(P<0.05).These findings will provide valuable reference data and key genetic variants that can be used to effectively select feed-efficient individual in sheep breeding programs.

关 键 词：sheep feed efficiency GWAS RE-SEQUENCING RFI FCR 

分 类 号：S826[农业科学—畜牧学]