新型冠状病毒感染诱发儿童1型糖尿病致病机制研究进展  

Advances in pathogenesis of type 1 diabetes mellitus in children induced by COVID-19

作　　者：杨勇 宋冬梅[2] Yang Yong;Song Dongmei(Department of Pediatrics,Wulanchabu Central Hospital,Wulanchabu 012000,China;Department of Pediatrics,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区：[1]乌兰察布市中心医院儿科,012000 [2]内蒙古医科大学附属医院儿科,呼和浩特010050

出　　处：《国际儿科学杂志》2025年第2期88-92,共5页International Journal of Pediatrics

摘　　要：糖尿病是由于胰岛素分泌绝对缺乏或相对不足所造成的糖、脂肪、蛋白质代谢紊乱,1型糖尿病(type 1 diabetes mellitus,T1DM)是儿童糖尿病最主要类型,其病因机制复杂,遗传易感和环境因素促发是其发病的主要原因,而呼吸道病毒感染可能是导致T1DM的环境因素之一。大量流行病学研究表明,在新型冠状病毒感染大流行期间,新发儿童T1DM、糖尿病酮症酸中毒病例明显增加,提示新型冠状病毒感染可能是儿童T1DM的诱发因素。该文综合国内外文献,从儿童糖尿病概述、新型冠状病毒感染与T1DM流行病学研究、诱发T1DM致病机制等方面进行阐述,为儿童T1DM预防管理及治疗提供新的策略与思路。Diabetes is a disorder of the metabolism of sugar,fat and protein caused by the absolute or relative lack of insulin secretion.Type 1 diabetes mellitus(T1DM)is the most important type of childhood diabetes,and its etiological mechanism is complex.Genetic susceptibility and environmental factors are the main causes of its pathogenesis,and respiratory virus infection may be one of the environmental factors leading to T1DM.A large number of epidemiological studies have shown that during the novel coronavirus infection(COVID-19)pandemic,new cases of T1DM and diabetic ketoacidosis in children have increased significantly,suggesting that COVID-19 may be a predispose factor for T1DM in children.Based on the literature at home and abroad,this paper discusses the overview of childhood diabetes,epidemiological studies on COVID-19 and T1DM,and the pathogenesis of T1DM,so as to provide new strategies and ideas for the prevention,management and treatment of T1DM in children induced by COVID-19.

关 键 词：儿童 新型冠状病毒感染 1型糖尿病 自身免疫 分子机制 

分 类 号：R725.8[医药卫生—儿科]