生命早期肠道菌群与早产儿神经发育的研究进展  

Progress on gut microbiota in early life and neurodevelopment of premature infants

作　　者：王雨倩 肖绪武 Wang Yuqian;Xiao Xuwu(Neonatology Department,the Second Hosptial of Dalian Medical University,Dalian 116000,China;Pediatric Department,Dalian Women and Children's Medical Group,Dalian 116000,China)

机构地区：[1]大连医科大学附属第二医院新生儿科,116000 [2]大连市妇女儿童医疗中心(集团)儿科,116000

出　　处：《国际儿科学杂志》2025年第2期93-97,共5页International Journal of Pediatrics

基　　金：辽宁省教育厅基本科研项目(LJKMZ20221294)。

摘　　要：肠道菌群对儿童健康具有重要意义。越来越多的研究表明肠道菌群是影响人类神经发育和神经精神疾病的潜在介质之一。在生命早期,肠道菌群和神经系统发育窗口期有显著的重叠。早产儿发生肠道菌群失调和神经发育障碍的风险较高。然而人类生命早期肠道菌群与神经发育之间的关系仍未明确。该文综述了生命早期肠道菌群与早产儿神经发育之间的关系,以期有助于明确早产儿健康神经发育的预测性生物标志物和潜在治疗靶点。The gut microbiota is of great significance for children's health.An increasing number of studies indicate that gut microbiota is one of the potential mediators affecting human neurodevelopment and neuropsychiatric dysbiosis.In early life,there is a significant overlap between the development window of gut microbiota and the nervous system.Premature infants are at high risk of developing gut microbiota dysbiosis and neurodevelopmental disorders.However,the connection between gut microbiota in early human life and neural development remains unclear.This article reviews the relationship between gut microbiota in early life and neurodevelopment in premature infants,with the aim of contributing to identify predictive biomarkers and potential therapeutic targets for healthy neurological development in premature infants.

关 键 词：肠道菌群 微生物-肠-脑轴 神经发育 生命早期 早产儿 

分 类 号：R722.6[医药卫生—儿科]