Comparison of objectively measured and estimated cardiorespiratory fitness to predict all-cause and cardiovascular disease mortality in adults:A systematic review and meta-analysis of 42 studies representing 35 cohorts and 3.8 million observations  

作　　者：Ben Singh Cristina Cadenas-Sanchez Bruno G.G.da Costa JoséCastro-Pinero Jean-Philippe Chaput Magdalena Cuenca-García Carol Maher Nuria Marín-Jim enez Ryan McGrath Pablo Molina-García Jonathan Myers Bethany Gower Francisco B.Ortega Justin J.Lang Grant R.Tomkinson 

机构地区：[1]Alliance for Research in Exercise,Nutrition and Activity(ARENA),UniSA Allied Health and Human Performance,University of South Australia,Adelaide,SA 5000,Australia [2]Department of Physical Education and Sports,Faculty of Sport Sciences,Sport and Health University Research Institute(iMUDS),University of Granada,Granada 18071,Spain [3]Department of Cardiology,Stanford University,Stanford,CA 94305,USA [4]Veterans Affairs Palo Alto Health Care System,Palo Alto,CA 94304,USA [5]Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición(CIBERobn),Instituto de Salud CarlosⅢ,Granada 18071,Spain [6]Department of Kinesiology and Physical Education,McGill University,Montreal,QC H2W 1S4,Canada [7]GALENO Research Group,Department of Physical Education,Faculty of Education Sciences,University of Cadiz,Puerto Real 11519,Spain [8]Instituto de Investigación e Innovación Biomédica de Cádiz(INiBICA),Cadiz 11009,Spain [9]Healthy Active Living and Obesity Research Group,Children’s Hospital of Eastern Ontario Research Institute,Ottawa,ON K1H 8L1,Canada [10]Department of Pediatrics,Faculty of Medicine,University of Ottawa,Ottawa,ON K1H 8L1,Canada [11]Healthy Aging North Dakota(HAND),North Dakota State University,Fargo,ND 58102,USA [12]Department of Health,Nutrition,and Exercise Sciences,North Dakota State University,Fargo,ND 58108,USA [13]Fargo VA Healthcare System,Fargo,ND 58102,USA [14]Department of Geriatrics,University of North Dakota,Grand Forks,ND 58202,USA [15]Instituto de Investigacion Biosanitaria ibs.Granada,Granada 18014,Spain [16]Faculty of Sport and Health Sciences,University of Jyvaskyla 40014,Finland [17]Centre for Surveillance and Applied Research,Public Health Agency of Canada,Ottawa,ON K1A 0K9,Canada [18]School of Epidemiology and Public Health,Faculty of Medicine,University of Ottawa,Ottawa,ON K1H 8M5,Canada

出　　处：《Journal of Sport and Health Science》2025年第2期135-148,共14页运动与健康科学(英文)

基　　金：supported by a grant from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska Curie(Grant agreement No.101028929);supported by an Investigator Grant from the Medical Research Future Fund(MRF1193862);supported by an Australian Government Research Training Program Scholarship.

摘　　要：Background:Cardiorespiratory fitness(CRF)is a powerful health marker recommended by the American Heart Association as a clinical vital sign.Comparing the predictive validity of objectively measured CRF(the"gold standara")and estimated CRF is clinically relevant because estimated CRF is more feasible.Our objective was to meta-analyze cohort studies to compare the associations of objectively measured,exerciseestimated,and non-exercise-estimated CRF with all-cause and cardiovascular disease(CVD)mortality in adults.Methods:Systematic searches were conducted in 9 databases(MEDLINE,SPORTDiscus,Embase,Scopus,PsycINFO,Web of Science,PubMed,CINAHL,and the Cochrane Library)up to April 11,2024.We included full-text refereed cohort studies published in English that quantified the association(using risk estimates with 95%confidence intervals(95%CIs))of objectively measured,exercise-estimated,and non-exercise-estimated CRF with all-cause and CVD mortality in adults.CRF was expressed as metabolic equivalents(METs)of task.Pooled relative risks(RR)for all-cause and CVD mortality per 1-MET(3.5 mL/kg/min)higher level of CRF were quantified using random-effects models.Results:Forty-two studies representing 35 cohorts and 3,813,484 observations(81%male)(362,771 all-cause and 56,471 CVD deaths)were included.The pooled RRs for all-cause and CVD mortality per higher MET were 0.86(95%CI:0.83-0.88)and 0.84(95%CI:0.80-0.87),respectively.For both all-cause and CVD mortality,there were no statistically significant differences in RR per higher MET between objectively measured(RR range:0.86-0.90)and maximal exercise-estimated(RR range:0.85-0.86),submaximal exercise-estimated(RR range:0.91-0.94),and non-exercise-estimated CRF(RR range:0.81-0.85).Conclusion:Objectively measured and estimated CRF showed similar dose-response associations for all-cause and CVD mortality in adults.Estimated CRF could provide a practical and robust alternative to objectively measured CRF for assessing mortality risk across diverse populations.Our findings underscore

关 键 词：Cardiorespiratory fitness Cardiovascular diseases Cohort studies Risk assessment ADULT 

分 类 号：R54[医药卫生—心血管疾病]