N‑terminal pro‑brain natriuretic peptide–a significant biomarker of disease development and adverse prognosis in patients with exertional heat stroke  

作　　者：Long Feng Jian-Yuan Yin Yao-Hong Liu Pei Zhang Ya-Li Zhao Qing Song Ping Ping Shi-Hui Fu 

机构地区：[1]Department of Anesthesiology,Hainan Hospital of Chinese PLA General Hospital,Sanya 572013,Hainan,China [2]Department of Critical Care,Hainan Hospital of Chinese PLA General Hospital,Sanya 572013,Hainan,China [3]School of Life Science,Beijing Institute of Technology,Beijing 100081,China [4]Central Laboratory,Hainan Hospital of Chinese PLA General Hospital,Sanya 572013,Hainan,China [5]Heatstroke Treatment and Research Center of Chinese PLA,Hainan Hospital of Chinese PLA General Hospital,Sanya 572013,Hainan,China [6]General Station for Drug and Instrument Supervision and Control,Joint Logistic Support Force of Chinese PLA,Beijing 100076,China [7]Department of Cardiology,Hainan Hospital of Chinese PLA General Hospital,Sanya 572013,Hainan,China [8]Department of Geriatric Cardiology,Chinese PLA General Hospital,Beijing 100853,China

出　　处：《Military Medical Research》2025年第3期461-463,共3页军事医学研究(英文版)

基　　金：supported by the Natural Science Foundation of Hainan Province(821QN389,821MS112,822MS198,820MS126,820QN383);the Military Medical Science and Technology Youth Incubation Program(20QNPY110,19QNP060);the Excellent Youth Incubation Program of Chinese PLA General Hospital(2020-YQPY-007);the Heatstroke Treatment and Research Center of Chinese PLA(413EGZ1D10);the Simulation Training for Treatment of Heatstroke,the Major Science and Technology Programme of Hainan Province(ZDKJ2019012);the National Key Research and Development Program of China(2018YFC2000400);the National S&T Resource Sharing Service Platform Project of China(YCZYPT[2018]07);the Specific Research Fund of Innovation Platform for Academicians of Hainan Province(YSPTZX202216);the Medical Big Data Research and Development Project of Chinese PLA General Hospital(MBD2018030).

摘　　要：Dear Editor,The most serious heat related injury is exertional heat stroke(EHS).EHS occurs when healthy individuals perform physical activity in a hot and humid environment[1].A disrupted balance between heat production and dissipation in the human body results in excessive body heat storage in cases.It occurs frequently in the military population because of work characteristics such as the requirements to perform essential duties under prolonged heat stress,the need to achieve mission objectives during deployment operations,or the opportunities for training and selection for elite units[2].The pathophysiology of EHS is complex,which often results in thermoregulation failure,hemodynamic disturbance,and endotoxin release,and further causes multiple organ failure,probably increasing myocardial enzymes and N-terminal pro-brain natriuretic peptide(NT-proBNP)levels.Rhabdomyolysis caused by EHS often results from mechanical and metabolic injury to the striated muscle fibers accompanied with the release of muscle contents into the circulation[3].Liu et al.

关 键 词：Exertional heat stroke MORTALITY Myocardial enzymes N-terminal pro-brain natriuretic peptide(NTproBNP) Physical activity 

分 类 号：R594.1[医药卫生—内科学] R594.3[医药卫生—临床医学]