血清NGB和MBP异常表达与HIE患儿脑神经发育的关系研究  

Relationship between abnormal expression of serum NGB and MBP and the cerebral neurodevelopment of neonates with HIE

作　　者：贺碧海 张妮妮 史楠楠 宋彩虹 贺兆平 李欣[1] HE Bihai;ZHANG Nini;SHI Nannan;SONG Caihong;HE Zhaoping;LI Xin(Department of Pediatrics,Yulin Hospital,the First Affiliated Hospital of Xi'an Jiaotong University,Yulin,Shaanxi 719000,China;Department of Neonatology,Yulin Hospital,the First Affiliated Hospital of Xi'an Jiaotong University,Yulin,Shaanxi 719000,China)

机构地区：[1]西安交通大学第一附属医院榆林医院儿科,陕西榆林719000 [2]西安交通大学第一附属医院榆林医院新生儿科,陕西榆林719000

出　　处：《国际检验医学杂志》2025年第7期796-800,共5页International Journal of Laboratory Medicine

基　　金：陕西省重点研发计划项目(S2022-YF-YBSF-1053)。

摘　　要：目的 探究血清神经血红蛋白(NGB)和髓鞘碱性蛋白(MBP)异常表达与缺氧缺血性脑病(HIE)患儿脑神经发育的关系。方法 选择2023年1月至2024年3月该院收治的89例HIE早产患儿作为观察组,同期选择60例无HIE早产儿作为对照组;检测两组血清MBP、NGB、促泌素水平,评估振幅整合脑电图评分;新生儿神经功能采用新生儿20项行为神经测定(NBNA)进行评估。采用Spearman法和受试者工作特征(ROC)曲线行相关性检验及诊断价值评估。结果 观察组血清NGB、MBP、促泌素水平高于对照组(P<0.05),振幅整合脑电图评分低于对照组(P<0.05);轻度组、中度组及重度组血清MBP、NGB、促泌素水平依次升高(P<0.05),NBNA评分、振幅整合脑电图评分依次降低(P<0.05);NGB、MBP、促泌素水平是影响NBNA评分的危险因素(P<0.05),振幅整合脑电图评分是影响NBNA评分的保护因素(P<0.05);NGB和MBP诊断HIE的曲线下面积均大于0.8,具有较高的应用价值。结论 血清NGB和MBP水平与HIE的严重程度密切相关,且与NBNA评分存在一定联系,NGB和MBP水平在HIE患儿中升高可能与机体对神经损伤的应激反应有关,可在一定程度反映HIE患儿脑神经功能损伤。Objective To analyze the relationship between abnormal expression of serum neurohemoglobin(NGB) and myelin basic protein(MBP) and the cerebral neurodevelopment of neonates with hypoxic-ischemic encephalopathy(HIE).Methods A total of 89 preterm infants with HIE admitted in the hospital between January 2023 and March 2024 were selected as the observation group,and 60 preterm infants without HIE during the same period were selected as the control group.Serum levels of MBP,NGB and secretagogues in two groups were detected,and the neonates amplitude integration electroencephalogram score was evaluated.The neurological function of neonates was evaluated using 20 items of Neonatal Behavioral Neurological Assessment(NBNA).The correlation test and diagnostic value were evaluated using Spearman method and receiver operating characteristic(ROC) curve.Results The serum levels of NGB,MBP and secretagogue in the observation group were higher than those in the control group(P<0.05),and the amplitude integration electroencephalogram score was lower than that in the control group(P<0.05).The serum MBP,NGB and secretagogue levels in the mild,moderate,and severe groups increased sequentially(P<0.05),NBNA score and amplitude integration electroencephalogram score decreased sequentially(P<0.05).The levels of NGB,MBP and secretagogue were the risk factors affecting NBNA score(P<0.05),and the amplitude integration electroencephalogram score was a protective factor affecting NBNA score(P<0.05).The area under the curve of NGB and MBP in diagnosing HIE was greater than 0.8,which had high application value.Conclusion Serum NGB and MBP levels are closely related to the severity of HIE,and have certain connection with NBNA score.Elevated levels of NGB and MBP in neonates with HIE may be related to the body′s stress response to nerve damage,which could reflect to some extent the brain nerve function damage in with HIE.

关 键 词：神经血红蛋白 髓鞘碱性蛋白 缺氧缺血性脑病 脑神经发育 

分 类 号：R446.1[医药卫生—诊断学] R722.1[医药卫生—临床医学]