血清HBP、SAA、CRP在COPD合并肺部感染患者中的表达及意义  

Expression and significance of serum HBP,SAA and CRP in patients with COPD complicated with pulmonary infection

作　　者：祝波 刘其洋 张凤华 ZHU Bo;LIU Qiyang;ZHANG Fenghua(Department of Clinical Laboratory,Shanghai Pudong New Area Zhoupu Hospital,Shanghai 200127,China)

机构地区：[1]上海市浦东新区周浦医院医学检验科,上海200127

出　　处：《国际检验医学杂志》2025年第7期823-827,833,共6页International Journal of Laboratory Medicine

基　　金：上海市浦东新区卫生系统重要薄弱学科建设项目(PWZbr2022-03)。

摘　　要：目的 探究血清肝素结合蛋白(HBP)、血清淀粉样蛋白A(SAA)、C反应蛋白(CRP)在慢性阻塞性肺疾病(COPD)合并肺部感染患者中的水平,分析三者在预后评估中的应用效果,以期为临床提供一种有效、可行的预后评估工具。方法 选取2021年1月至2023年12月在该院收治的117例COPD合并肺部感染患者作为观察组,另选取该院同期未合并肺部感染的COPD患者117例作为对照组。对比两组患者HBP、SAA、CRP水平;根据观察组患者28 d存活情况进一步分为死亡组和存活组,分析影响COPD合并肺部感染患者死亡的相关因素,采用受试者工作特征(ROC)曲线评估HBP、SAA、CRP单项及联合预测COPD合并肺部感染患者短期预后的效能。结果 观察组HBP、SAA、CRP水平较对照组更高(P<0.05);117例COPD合并肺部感染患者28 d死亡28例(23.93%),存活89例(76.07%);死亡组年龄大于存活组(P<0.05),有侵入性操作、COPD病程≥10年、临床肺部感染评分(CPIS)为中-重度的占比高于存活组(P<0.05),血清HBP、SAA、CRP水平高于存活组(P<0.05);年龄、侵入性操作、COPD病程、CPIS、HBP、SAA、CRP为影响COPD合并肺部感染患者死亡的独立危险因素(P<0.001);HBP、SAA、CRP联合预测COPD合并肺部感染患者短期预后的曲线下面积大于三者单项检测(P<0.05)。结论 COPD合并肺部感染患者血清HBP、SAA、CRP水平与预后死亡风险密切相关,分析三者水平能为COPD合并肺部感染患者制订个体化临床治疗提供有力支持。Objective To analyze the levels of serum heparin-binding protein(HBP),serum amyloid A(SAA) and C-reactive protein(CRP) in patients with chronic obstructive pulmonary disease(COPD) complicated with pulmonary infection,and to analyze the application effect of the three in prognosis evaluation,in order to provide an effective and feasible prognosis evaluation tool for clinical practice.Methods A total of 117 COPD patients complicated with pulmonary infection admitted to the hospital from January 2021 to December 2023 were selected as the observation group,and 117 COPD patients without pulmonary infection in the hospital during the same period were selected as the control group.HBP,SAA and CRP levels were compared in two groups.According to the 28-day survival of the patients in the observation group,the patients were divided into death group and survival group,and the related factors affecting the death of COPD patients complicated with pulmonary infection were analyzed.The receiver operating characteristic(ROC) curve was used to evaluate the efficacy of single and combined prediction of HBP,SAA,CRP for short-term prognosis in COPD patients complicated with pulmonary infection.Results The levels of HBP,SAA,and CRP in the observation group were higher than those in the control group(P<0.05).Among 117 COPD patients complicated with pulmonary infection,28 cases(23.93%) died after 28 days,and 89 cases(76.07%) survived.The age in the death group was older than that in the survival group(P<0.05),and the proportions of patients with invasive procedures,COPD duration ≥ 10 years,and clinical pulmonary infection score(CPIS) of moderate to severe were higher than those in the survival group(P<0.05),and the levels of serum HBP,SAA,and CRP were higher than those in the survival group(P<0.05).Age,invasive procedures,COPD duration,CPIS,HBP,SAA,and CRP were independent risk factors for death in COPD patients complicated with pulmonary infection(P<0.001).The area under the curve of combined prediction of HBP,SAA and CRP for short-

关 键 词：肝素结合蛋白 血清淀粉样蛋白A C反应蛋白 慢性阻塞性肺疾病 肺部感染 

分 类 号：R563[医药卫生—呼吸系统]