血清FAR、MFG-E8联合检测在预测先兆流产患者保胎结局中的价值  

Value of combined detection of serum FAR and MFG-E8 in predicting the fetal protection outcome of threatened abortion patients

作　　者：陈贝 李翠娥 曹阳 汪晶 CHEN Bei;LI Cui'e;CAO Yang;WANG Jing(Department of Obstetrics and Gynecology,Jianli People's Hospital,Jianli,Hubei 430000,China;Department of Obstetrics and Gynecology,Wuhan University People's Hospital,Wuhan,Hubei 430060,China)

机构地区：[1]监利市人民医院妇产科,湖北监利430000 [2]武汉大学人民医院妇产科,湖北武汉430060

出　　处：《国际检验医学杂志》2025年第7期828-833,共6页International Journal of Laboratory Medicine

基　　金：湖北省自然科学基金项目(WJ2019A265)。

摘　　要：目的 探究血清纤维蛋白原/白蛋白比值(FAR)、乳脂肪球表皮生长因子8(MFG-E8)联合检测在预测先兆流产患者保胎结局中的价值。方法 选取2022年5月至2023年5月在监利市人民医院接受保胎治疗的89例先兆流产患者作为观察组,根据保胎结局分为流产组(19例)、成功组(70例);选择同期接受定期产检的89例正常妊娠者作为对照组。采用酶联免疫吸附试验(ELISA)检测血清纤维蛋白原、白蛋白、MFG-E8水平,计算FAR;采用多因素Logistic回归分析先兆流产患者保胎结局的影响因素;采用受试者工作特征(ROC)曲线分析血清FAR、MFG-E8水平对先兆流产患者保胎结局的预测价值。结果 与对照组比较,观察组血清FAR较高(P<0.05),血清MFG-E8水平较低(P<0.05);流产组甲状腺功能异常比例、血清C反应蛋白(CRP)、FAR高于成功组(P<0.05),血清MFG-E8水平低于成功组(P<0.05);血清FAR、CRP、甲状腺功能异常是先兆流产患者保胎结局的危险因素(P<0.05),而血清MFG-E8是先兆流产患者保胎结局的保护因素(P<0.05);血清FAR、MFG-E8及二者联合预测先兆流产患者保胎结局的曲线下面积(AUC)分别为0.787、0.853、0.954,二者联合优于血清FAR、MFG-E8各自单独预测(Z_(二者联合-FAR)=2.805、Z_(二者联合-MFG-E8)=2.076,P=0.005、0.038),其灵敏度、特异度分别为94.74%、88.57%。结论 先兆流产患者血清FAR升高,MFG-E8水平降低,二者联合对先兆流产患者保胎结局具有更高的预测价值。Objective To evaluate the value of combined detection of serum fibrinogen/albumin ratio(FAR) and milk fat globule epidermal growth factor 8(MFG-E8) in predicting the fetal protection outcome of threatened abortion patients.Methods From May 2022 to May 2023,a total of 89 patients with threatened abortion who received fetal protection treatment in Jianli People′s Hospital were regarded as the observation group.They were grouped into a miscarriage group(19 cases) and a successful group(70 cases) based on the fetal protection outcomes.89 normal pregnant women who underwent prenatal examinations were regarded as the control group.Enzyme-linked immunosorbent assay was applied to detect the levels of serum fibrinogen,albumin and MFG-E8.Multivariate Logistic regression was applied to analyze the influencing factors on the fetal protection outcome of patients with threatened abortion.Receiver operating characteristic(ROC) curve was applied to analyze the predictive value of serum FAR and MFG-E8 level on the fetal protection outcome of patients with threatened abortion.Results Compared with the control group,serum FAR was higher in the observation group(P<0.05) and serum MFG-E8 level was lower(P<0.05).The proportion of thyroid dysfunction,serum C-reactive protein(CRP),and FAR in the miscarriage group were higher than those in the successful group(P<0.05),while serum MFG-E8 level was lower than that in the successful group(P<0.05).Serum FAR,CRP and thyroid dysfunction were risk factors for fetal protection outcome of patients with threatened abortion,while serum MFG-E8 was a protective factor for fetal protection outcome of patients with threatened abortion(P<0.05).The area under the curve(AUC) of serum FAR,MFG-E8,and their combination in predicting the fetal protection outcome of patients with threatened abortion was 0.787,0.853,and 0.954,respectively,and the efficacy of combination of the two in predicting the fetal protection outcome of patients with threatened abortion was better than that of serum FAR and MFG-E8 alon

关 键 词：先兆流产 纤维蛋白原/白蛋白比值 乳脂肪球表皮生长因子8 保胎结局 

分 类 号：R714.2[医药卫生—妇产科学]