KL-6联合CRP和血常规评估甲型流感患者早期肺损伤的意义  

Significance of KL-6 combined with CRP and blood routine in evaluating early lung injury in patients with influenza A

作　　者：韩忠燕 李梦雪 唐瑶 王守星 HAN Zhongyan;LI Mengxue;TANG Yao;WANG Shouxing(Department of Clinical Laboratory,Sir Run Run Hospital,Nanjing Medical University,Nanjing,Jiangsu 210000,China)

机构地区：[1]南京医科大学附属逸夫医院检验科,江苏南京210000

出　　处：《国际检验医学杂志》2025年第7期840-844,共5页International Journal of Laboratory Medicine

摘　　要：目的 探讨涎液化糖链抗原(KL-6)、C反应蛋白(CRP)和血常规中部分指标联合检测在甲型流感病毒感染患者肺损伤中的诊断价值。方法 选取2023年12月该院收治的92例甲型流感患者作为观察组,根据X线检查是否出现肺内斑片状、磨玻璃影等明显纹理改变特征,将甲型流感患者分为肺损伤阳性组(T1组,30例)和肺损伤阴性组(T2组,62例),另选取53例同期体检健康者作为对照组。检测外周血血常规、CRP和KL-6水平。比较观察组和对照组,以及T1组和T2组血常规、KL-6、CRP水平,采用受试者工作特征(ROC)曲线分析单项指标与联合检测对甲型流感患者肺损伤的诊断效能。结果 与对照组比较,观察组白细胞计数、中性粒细胞百分比、单核细胞百分比、中性粒细胞/淋巴细胞比值(NLR)、单核细胞/淋巴细胞比值(MLR)、血小板/淋巴细胞比值(PLR)、CRP及KL-6水平升高,淋巴细胞百分比、血小板计数降低(P<0.05)。与T2组比较,T1组贫血发生率、CRP、KL-6水平升高(P<0.05)。二元Logistic回归分析结果显示,血常规单独检测,KL-6和CRP均是甲型流感患者肺损伤的影响因素(P<0.05),KL-6、CRP、血常规单独检测,KL-6联合CRP及KL-6、CRP、血常规三者联合诊断甲型流感患者肺损伤的曲线下面积分别为0.679、0.641、0.604、0.727和0.781。结论 KL-6联合CRP和血常规检测对甲型流感患者肺损伤诊断效能较高,具有较大的临床意义。Objective To explore the diagnostic value of combined detection of Krebs Von den Lungen-6(KL-6),C-reactive protein(CRP),and some indicators in blood routine for lung injury in patients with influenza A virus infection.Methods A total of 92 patients with influenza A admitted to the hospital in December 2023 were selected as the observation group.Based on whether there were obvious texture changes such as patchy and ground glass opacities in the lungs on X-ray examination,the patients were divided into a lung injury positive group(T1 group,30 cases) and a lung injury negative group(T2 group,62 cases).Additionally,53 healthy individuals who underwent physical examinations during the same period were selected as the control group.Peripheral blood routine,CRP,and KL-6 levels were detected.Peripheral blood routine,CRP,and KL-6 levels were compared between the observation group and control group,and between T1 group and T2 group.receiver operating characteristic(ROC) curve were used to evaluate the diagnostic efficacy of individual indicators and combined detection for patients with lung injury who infected with influenza A.Results Compared with the control group,white blood cell count,neutrophil ratio,monocyte ratio,neutrophil/lymphoid ratio(NLR),monocyte/lymphoid ratio(MLR),platelet/lymphoid ratio(PLR),CRP and KL-6 levels in the observation group were increased,while the lymphocyte ratio and platelet count decreased(P<0.05).Compared with the T2 group,the CRP and KL-6 levels increased and the incidence of anemia increased in the T1 group(P<0.05).The results of binary Logistic regression analysis showed that blood routine,KL-6,and CRP were all influencing factors of lung injury in patients with influenza A(P<0.05).The area under the curve of single detection of KL-6,CRP,blood routine,the combined detection of KL-6 and CRP,and the combined detection of KL-6,CRP and blood routine were 0.679,0.641,0.604,0.727 and 0.781.Conclusion KL-6 combined with CRP and blood routine testing has high diagnostic efficacy for lung injury

关 键 词：甲型流感病毒 肺损伤 涎液化糖链抗原 血常规 C反应蛋白 

分 类 号：R446.1[医药卫生—诊断学]