Should workers be physically active after work?Associations of leisure-time physical activity with cardiovascular and all-cause mortality across occupational physical activity levels-An individual participant data meta-analysis  

作　　者：Bart Cillekens Pieter Coenen Maaike A.Huysmans Andreas Holtermann Richard P.Troiano Paul Jarle Mork Steinar Krokstad Els Clays Dirk De Bacquer Mette Aadahl Line Lund Kårhus Anette Sjøl Lars Bo Andersen Jussi Kauhanen Ari Voutilainen Richard Pulsford Emmanuel Stamatakis Uri Goldbourt Annette Peters Barbara Thorand Annika Rosengren Lena Björck Kyle Sprow Kristin Franzon Miguel Rodriguez-Barranco Leila Luján-Barroso Lars Alfredsson Martin Bahls Till Ittermann Miriam Wanner Matthias Bopp Jacob Louis Marott Peter Schnohr Børge G.Nordestgaarda Knut Eirik Dalene Ulf Ekelund Johan Clausen Magnus T.Jensen Christina Bjørk Petersen Niklas Krause Jos Twisk Willem van Mechelen Allard J.van der Beek 

机构地区：[1]Department of Public and Occupational Health,Amsterdam Public Health Research Institute,Vrije Universiteit Amsterdam,Amsterdam UMC,Amsterdam 1081 HV,the Netherlands [2]National Research Centre for the Working Environment,Copenhagen 2100,Denmark [3]Department of Sports Science and Clinical Biomechanics,University of Southern Denmark,Odense 5230,Denmark [4]U.S.Public Health Service,Arlington,VA 22201,USA [5]Department of Public Health and Nursing,Norwegian University of Science and Technology,Trondheim 8905,Norway [6]Levanger Hospital,Nord-Trøndelag Hospital Trust,Levanger 7601,Norway [7]Department of Public Health and Primary Care,Ghent University,Ghent 9000,Belgium [8]Center for Clinical Research and Prevention,Bispebjerg and Frederiksberg Hospital,Frederiksberg 2000,Denmark [9]The Capital Region of Denmark,Copenhagen 1172,Denmark [10]Western Norway University of Applied Sciences,Faculty of Education,Arts and Sports,Sogndal 5414,Norway [11]Institute of Public Health and Clinical Nutrition,University of Eastern Finland,Kuopio 1627,Finland [12]Faculty of Health and Life Sciences,University of Exeter,Exeter EX12LU,UK [13]Mackenzie Wearables Research Hub,Charles Perkins Centre,The University of Sydney,NSW 2050,Australia [14]School of Health Sciences,Faculty of Medicine and Health,The University of Sydney,NSW 2050,Australia [15]Sackler Medical faculty in Tel Aviv University,Tel Aviv 6997801,Israel [16]Institute of Epidemiology,Helmholtz Zentrum München,German Research Center for Environmental Health,Neuherberg 85764,Germany [17]German Centre for Cardiovascular Research(DZHK e.V.),partner site Munich Heart Alliance,Munich 80636,Germany [18]Institute for Medical Information Processing,Biometry,and Epidemiology(IBE),Pettenkofer School of Public Health,Faculty of Medicine,Ludwig-Maximilians-Universität,Munich 80636,Germany [19]Institute of Medicine,Department of Molecular and Clinical Medicine,Sahlgrenska Academy,University of Gothenburg,Gothenburg 40530,Sweden [20]Region Västra Götaland,Sahlgrenska University Hos

出　　处：《Journal of Sport and Health Science》2025年第1期49-60,共12页运动与健康科学(英文)

基　　金：The Trùndelag Health Study (HUNT) is a collaboration between HUNT Research Centre (Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology), Trùndelag County Council, Central Norway Regional Health Authority, and the Norwegian Institute of Public Health;The coordination of European Prospective Investigation into Cancer and Nutrition - Spain study (EPIC) is financially supported by the International Agency for Research on Cancer (IARC);by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC);supported by Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII), Regional Governments of Andaluc 1a, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology - ICO (Spain);funded by The Netherlands Organisation for Health Research and Development;Zon Mw (Grant No.: 531-00141-3);Funding for the SHIP study has been provided by the Federal Ministry for Education and Research (BMBF;identification codes 01 ZZ96030, 01 ZZ0103, and 01 ZZ0701);support from the Swedish Research Council (2018-02527 and 2019-00193);financed by the Helmholtz Zentrum München - German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria.

摘　　要：Background There is insufficient evidence to provide recommendations for leisure-time physical activity among workers across various occupational physical activity levels.This study aimed to assess the association of leisure-time physical activity with cardiovascular and all-cause mortality across occupational physical activity levels.Methods This study utilized individual participant data from 21 cohort studies,comprising both published and unpublished data.Eligibility criteria included individual-level data on leisure-time and occupational physical activity(categorized as sedentary,low,moderate,and high)along with data on all-cause and/or cardiovascular mortality.A 2-stage individual participant data meta-analysis was conducted,with separate analysis of each study using Cox proportional hazards models(Stage 1).These results were combined using random-effects models(Stage 2).Results Higher leisure-time physical activity levels were associated with lower all-cause and cardiovascular mortality risk across most occupational physical activity levels,for both males and females.Among males with sedentary work,high compared to sedentary leisure-time physical activity was associated with lower all-cause(hazard ratios(HR)=0.77,95%confidence interval(95%CI):0.70-0.85)and cardiovascular mortality(HR=0.76,95%CI:0.66-0.87)risk.Among males with high levels of occupational physical activity,high compared to sedentary leisure-time physical activity was associated with lower all-cause(HR=0.84,95%CI:0.74-0.97)and cardiovascular mortality(HR=0.79,95%CI:0.60-1.04)risk,while HRs for low and moderate levels of leisure-time physical activity ranged between 0.87 and 0.97 and were not statistically significant.Among females,most effects were similar but more imprecise,especially in the higher occupational physical activity levels.Conclusion Higher levels of leisure-time physical activity were generally associated with lower mortality risks.However,results for workers with moderate and high occupational physical activity levels,especiall

关 键 词：Mortality Individual participant data Physical activity paradox Job demands 

分 类 号：R54[医药卫生—心血管疾病]