Advances and Challenges in mRNA Vaccine Technology  

作　　者：Ying Zhou Zhaoru Wu Yibo Wang Rongkang Lao Yunfei Huang Shun Li Qiang Fu Jiedan Liao 

机构地区：[1]School of Animal Science and Technology,Foshan University,Foshan 528225,Guangdong,China

出　　处：《Proceedings of Anticancer Research》2025年第2期27-42,共16页抗癌研究

基　　金：National Natural Science Foundation of Guangdong Province(No.2022A1515140052);Project of Science and Technology of Guangdong Province(No.KTP20240768);Project of Department of Education of Guangdong Province(No.2022ZDJS036)。

摘　　要：Since the outbreak of COVID-19,mRNA vaccine technology has achieved groundbreaking advancements.Characterized by its high safety profile and potent immune activation capabilities,this technology has demonstrated significant potential in the prevention of infectious diseases and cancer therapeutics,marking a new milestone in vaccine development.This review focuses on three key aspects—molecular design,delivery systems,and immunological mechanisms—providing a comprehensive analysis of structural optimization strategies,delivery methodologies,and immune modulation approaches for mRNA vaccines.Additionally,it summarizes and evaluates potential challenges that may arise in the future development of mRNA vaccines.By analyzing existing technological pathways,this review aims to advance innovation in mRNA vaccine technology and facilitate its broad applications in public health and veterinary medicine.

关 键 词：mRNA vaccine Molecular design Delivery systems Immune mechanisms 

分 类 号：R392-33[医药卫生—免疫学] S852.4[医药卫生—基础医学]