镭-223制备技术研究进展  

Research Progress in the Preparation Technology of Radium-223

作　　者：耿峻山 吴建荣 肖茜 李波[1,2,3] 陈云明 张劲松[1,2,3] 罗宁[1,2,3] GENG Junshan;WU Jianrong;XIAO Qian;LI Bo;CHEN Yunming;ZHANG Jingsong;LUO Ning(Nuclear Power Institute of China,Chengdu 610213,China;Radioisotope Engineering Technology Research Center of Sichuan,Chengdu 610213,China;National Engineering Research Center For Isotopes and Pharmaceuticals,Chengdu 610213,China)

机构地区：[1]中国核动力研究设计院,成都610213 [2]四川省放射性同位素工程技术研究中心,成都610213 [3]同位素及药物国家工程研究中心,成都610213

出　　处：《同位素》2025年第2期206-216,共11页Journal of Isotopes

摘　　要：^(223)Ra是一种具有较低毒性的α放射治疗核素,可以用于治疗伴有骨转移症状并无内脏转移的去势抵抗性前列腺癌(mCRPC),是第一个被批准上市的α治疗放射性药品。随着多菲戈(^(223)RaCl_(2)注射液)在美国上市,标志着α放射性核素治疗的广泛应用。相比于其他常用的β、γ医用放射性核素,^(223)Ra的制备分离研究还不足。^(223)Ra的制备过程存在原料获取困难、剂量较高、分离步骤繁琐、同位素杂质多等问题,本研究主要对从天然矿石中分离、加速器制备、反应堆辐照制备、从锕/铍发生器中获取^(223)Ra的制备方法及分离工艺进行综述,并讨论^(223)Ra制备面临的挑战,为高效分离^(223)Ra提供一定的参考。^(223)Ra is a low toxicity substanceαRadiotherapy nuclide,which can be used to treat castrated resistant prostate cancer(CRPC)with symptoms of bone metastasis and no visceral metastasis,was the first approved alpha therapy radiopharmaceutical on the market.In 2013,with the launch of Xofigo(^(223)RaCl_(2) solution)in the United States,it markedαradionuclide therapy has widely entered people’s field of vision.Compared to other commonly usedβ、γmedical radioactive isotopes,research on ^(223)Ra is still far from sufficient,especially in terms of preparation and separation.In the preparation process of ^(223)Ra,there are difficulties in obtaining raw materials,high dosage,cumbersome separation steps,and many isotopic impurities.In response to these difficulties,various methods for preparing ^(223)Ra have also been studied.This article mainly reviews the preparation methods and separation processes of ^(223)Ra through four methods:separation from natural ores,accelerator preparation,reactor irradiation preparation,and obtaining from actinium/beryllium generators.It also discusses some challenges and prospects in the preparation of ^(223)Ra,providing some reference for efficient separation of ^(223)Ra.

关 键 词：α放射性核素 制备分离 加速器 反应堆 放射性子体 

分 类 号：TL921[核科学技术—核燃料循环与材料]