基于表面增强拉曼散射光谱监测微流体环境中吸附动力学研究  

Adsorption Kinetics Monitoring in Microfluidic Environment Based on Surface-Enhanced Raman Scattering Spectroscopy

作　　者：刘康康 楚淑君 LIU Kangkang;CHU Shujun(Shandong Haike New Source Material Technology Co.,Ltd.,Shandong Dongying 257000;Dongying Qirun Chemical Co.,Ltd.,Shandong Dongying 257000,China)

机构地区：[1]山东海科新源材料科技股份有限公司,山东东营257000 [2]东营齐润化工有限公司,山东东营257000

出　　处：《广州化工》2025年第6期136-138,共3页GuangZhou Chemical Industry

摘　　要：吸附动力学是物理化学、生物化学和材料科学等领域中的一个重要研究方向。传统吸附动力学研究方法往往难以满足高灵敏度、实时监测和原位分析的需求。设计了一种表面增强拉曼散射(Surface-Enhanced Raman Scattering,SERS)与微流体相结合的原位化学检测方法,证明了微流控在实现分析物从样品导入点到检测点传输方面的可行性。采用该微流控装置监测分子罗丹明6G(R6G)在SERS活性底物上的吸附动力学,将612 cm^(-1)作为R6G分子的特征峰,R6G水溶液线性范围5×10^(-8)~5×10^(-6)mol·L^(-1)内,R6G水溶液浓度与SERS强度的相关系数R^(2)=0.9868,SERS强度与R6G表面吸附浓度的相关系数R^(2)=0.9911,并且发现吸附动力学结果显示,R6G浓度不同,达到最大吸附强度的时间也不同,应在吸附平衡后进行检测。总之,SERS活性底物集成在微流控的方法可以实现液体样品中分子吸附动力学的重复监测,并可以检测和报告未知目标分子的浓度。Adsorption kinetics represents a critical research area in physical chemistry,biochemistry and materials science.Conventional methods for studying adsorption kinetics often struggle to meet demands for high sensitivity,realtime monitoring and in situ analysis.Herein,a novel analytical approach integrating surface enhanced raman scattering(SERS)with microfluidic technology was presented.This system demonstrated efficient analyte transport from the sampling inlet to the detection zone via microfluidic channels.The developed platform was applied to monitor the adsorption kinetics of Rhodamine 6G(R6G)molecules on SERS-active substrates.R6G exhibited a distinct vibrational peak at 612 cm^(-1).Linear response over 5×10^(-8)~5×10^(-5)mol/L with R^(2)=0.9868(solution concentration)and R²=0.9911(surface adsorption concentration).Kinetics Behavior:Adsorption equilibrium times varied with concentration,highlighting the necessity of post-equilibrium detection.By embedding SERS-active substrates into microfluidic devices,this methodology enablesd reproducible kinetic monitoring of molecular adsorption in liquid samples.It also provided a basis for quantitative analysis of unknown target molecules through surface concentration-intensity correlations.This work advanced the field by bridging microfluidic handling with spectroscopic detection,offering new opportunities for dynamic adsorption studies in complex matrices.

关 键 词：表面增强拉曼散射 微流控 罗丹明6G 

分 类 号：O65[理学—分析化学]