中药复配剂及其乳膏的体外抑菌效果观察  

Observation on the bacteriostatic effect in vitro of compound traditional Chinese medicine and its cream

作　　者：吴先昊 陈芳军 黎云颖 俞佳峰 刘雯[1] 赵诗云[1] 曾爱忠 李雪[1] WU Xian-hao;CHEN Fang-jun;LI Yun-ying;YU Jia-feng;LIU Wen;ZHAO Shi-yun;ZENG Ai-zhong;LI Xue(Jiangxi Provincial Institute of Traditional Chinese Medicine,Nanchang 330046,China;Jiangxi Duyitang Biotechnology Co.,Ltd.)

机构地区：[1]江西省中医药研究院,江西南昌330046 [2]江西独依堂生物科技有限公司

出　　处：《中国消毒学杂志》2025年第3期165-167,共3页Chinese Journal of Disinfection

基　　金：江西省卫生健康委科技计划项目(202311191);江西省中医药管理局科技计划项目(2022B1035)。

摘　　要：目的 观察某中药复配剂及其乳膏的体外抑菌效果。方法 采用载体浸泡定量抑菌试验和最小抑菌浓度(MIC)试验方法,对某中药复配剂及其乳膏体外抑菌效果进行评价。结果 50 mg/mL中药复配剂溶液作用4 h,对载体上金黄色葡萄球菌、大肠埃希菌和白念珠菌的抑菌率分别为94.0%、89.0%和46.3%。该中药复配乳膏的抑菌率分别为42.9%、75.0%和17.7%。该中药复配剂对金黄色葡萄球菌、大肠埃希菌和白念珠菌的MIC分别为0.8、0.8和12.8mg/mL;该中药复配剂对金黄色葡萄球菌、大肠埃希菌和白念珠菌的最小杀菌浓度(MBC)分别为3.2、3.2和51.2 mg/mL。结论 该中药复配剂及其乳膏对金黄色葡萄球菌、大肠埃希菌和白念珠菌均有一定抑菌作用。Objective To observe the antibacterial effect of a compound of Chinese medicine and its cream in vitro.Methods Quantitative bacteriostatic test by carrier immersion and minimum inhibitory concentration(MIC)test were used to evaluate the bacteriostatic effect of a traditional Chinese medicine compound and its cream in vitro.Results The inhibition rates of Staphylococcus aureus,Escherichia coli and Candida albicans were 94.0%,89.0%and 46.3%,respectively,after being treated with 50 mg/mL compound solution for 4 h.The antibacterial rates of the compound cream were 42.9%,75.0%and 17.7%,respectively.The MIC of a Chinese herbal compound against Staphylococcus aureus,Escherichia coli and Candida albicans were 0.8,0.8 and 12.8 mg/mL,respectively.The minimum bactericide concentration(MBC)of Staphylococcus aureus,Escherichia coli and Candida albicans were 3.2,3.2 and 51.2 mg/mL,respectively.Conclusion The compound of traditional Chinese medicine and its cream have certain bacteriostatic effects on Staphylococcus aureus,Escherichia coli and Candida albicans.

关 键 词：中药复配剂 中药乳膏 抑菌效果 

分 类 号：R283[医药卫生—中药学] R187[医药卫生—中医学]