中药及复方调控心肌细胞焦亡改善糖尿病心肌病的研究分析与探讨  

Analysis and Discussion of Traditional Chinese Medicine and Compounds to Improve Diabetic Cardiomyopathy by Regulating Cardiomyocyte Pyroptosis

作　　者：张莹[1] 谢成志 付畅 任建勋[1] ZHANG Ying;XIE Chengzhi;FU Chang;REN Jianxun(Institute of Basic Medical Sciences of Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]中国中医科学院西苑医院,基础医学研究所,北京100091

出　　处：《中国实验方剂学杂志》2025年第8期260-267,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重大新药创制“科技重大专项”项目(2018ZX09731-018);中国中医科学院创新工程项目(C12021A0413);中国中医科学院西苑医院中药新药研发与转化专项(XYZX0303-08)。

摘　　要：糖尿病性心肌病(DCM)是一种由糖尿病引起的心肌特异性微血管疾病,会影响心脏的结构和功能,被认为是糖尿病患者发病和死亡的主要原因。中医药治疗DCM有临床丰富的经验和确切的疗效,其多靶点、多途径、多组分、不良反应小的特点可以延缓DCM发展进程、改善症状,有效应对其病理过程的复杂性和长期性。近来许多研究发现伴随着炎症反应的细胞焦亡是DCM心肌损伤的主要形式之一,促进DCM发生发展,并与DCM过程中氧化应激、心肌纤维化、心肌肥厚及心功能下降等病理变化密切相关。这些研究也为中医药探索DCM的潜在治疗方法和干预机制提供了理论依据。该研究通过对CNKI、PubMed,Web of Science,Excerpt Medica,Science Direct和Springer等多个数据库相关文献的检索和分析,旨在综合分析近年来中药及复方干预DCM心肌细胞焦亡的作用特点,并探讨其潜在的机制,从心肌细胞焦亡的角度揭示了中药有效成分及复方防治DCM的潜力,为中医药治疗DCM的临床应用提供新思路和更多的实验证据。Diabetic cardiomyopathy(DCM)is a myocardium-specific microvascular disease caused by diabetes mellitus that impairs the structure and function of the heart.It is the major cause of morbidity and mortality in diabetic individuals.Traditional Chinese medicine(TCM)has extensive clinical experience and precise efficacy in treating DCM,and its multi-target,multi-pathway,multi-component,and low side effect approach can slow the progression of DCM and improve the symptoms while effectively dealing with the complexity and long-term nature of its pathological process.Many recent studies have demonstrated that pyroptosis accompanied by inflammatory response is one of the main types of myocardial injury in DCM,which promotes the development of DCM and is closely related to pathological changes such as oxidative stress,myocardial fibrosis,myocardial hypertrophy,and decreased cardiac function in the course of DCM.These findings also provide a theoretical foundation for future research into potential therapy techniques and intervention mechanisms for DCM.By searching and analyzing relevant literature from several databases,including CNKI,PubMed,Web of Science,Excerpt Medica,Science Direct,and Springer,this study aimed to comprehensively analyze the characteristics of the effects of TCM and compounds in intervening in cardiomyocyte pyroptosis in DCM in recent years and explore the potential mechanisms.It also reveals the potential of effective components of TCM and compounds in preventing and controlling DCM from the standpoint of cardiomyocyte pyroptosis and provides a new way of thinking and more experimental evidence for the clinical application of TCM in treating DCM.

关 键 词：糖尿病心肌疾病 心肌细胞焦亡 中药 进展 机制 

分 类 号：R259[医药卫生—中西医结合] R282[医药卫生—中医内科学] R335[医药卫生—中医学]