基于“肠-脑轴”探讨中医药干预腹泻型肠易激综合征的研究进展  

Traditional Chinese Medicine Intervention in Diarrhea-predominant Irritable Bowel Syndrome Based on Gut-brain Axis:A Review

作　　者：彭金婵 韦金秀 刘柱 刘礼剑[2] 黎丽群 杨成宁 陈广文[2] 李建锋 谢胜[2] PENG Jinchan;WEI Jinxiu;LIU Zhu;LIU Lijian;LI Liqun;YANG Chengning;CHEN Guangwen;LI Jianfeng;XIE Sheng(Graduate School of Guangxi University of Chinese Medicine,Nanning 530001,China;The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530001,China)

机构地区：[1]广西中医药大学研究生院,南宁530001 [2]广西中医药大学第一附属医院,南宁530001

出　　处：《中国实验方剂学杂志》2025年第8期311-319,共9页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广西中医药管理局桂派中医大师工作室项目(GZY2024004);广西中医药管理局广西中医药适宜技术开发与推广项目(GZSY2025027);广西壮族自治区中医药管理局广西岐黄学者培养项目(2022015-003-01)。

摘　　要：腹泻型肠易激综合征(IBS-D)是常见的消化系统疾病,且患病率和复发率连年居高,医疗资源费用大,患者的生存质量和经济负担受到严重影响。因此,探索安全的新型治疗方法十分重要。该病发病机制复杂,其中“肠-脑轴”失调是IBS-D的主要发病机制。“肠-脑轴”是连接胃肠道和中枢神经系统的双向信号通路,从而调节胃肠运动、分泌和免疫反应等功能,在IBS-D发生发展中扮演关键角色。迄今,止泻剂、益生菌、神经递质调节药物等是临床上治疗IBS-D的主要方法,虽然能限制部分病情的进展,但治疗效果欠佳。诸多研究证实,中医药通过多途径、多靶点调控“肠-脑轴”干预IBS-D,调节胃肠运动,加强免疫防御而有效治疗IBS-D,具有显著优势。然而,目前尚缺乏对中医药调控“肠-脑轴”治疗IBS-D的系统综述。故该文通过检索近年来国内外数据库IBS-D相关文献,系统性总结“肠-脑轴”与IBS-D的关系及中医药在其中的作用,将为IBS-D的治疗提供新思路。Diarrhea-predominant irritable bowel syndrome(IBS-D)is a common digestive system disease with high prevalence and recurrence rates for years,high treatment costs,and serious impacts on patients'quality of life and economic burden.Therefore,it is important to explore new and safe treatment methods.The pathogenesis of IBS-D is complex,in which the gut-brain axis is a key factor.The gut-brain axis,a bidirectional signaling pathway connecting the gastrointestinal tract and the central nervous system,regulates gastrointestinal motility,secretion,and immune responses,playing a key role in the occurrence and development of IBS-D.Up to now,antidiarrheal agents,probiotics,and neurotransmitter modulators are the main methods for the clinical treatment of IBS-D.Although they can partially curb the progression of this disease,the therapeutic effects remain to be improved.Studies have confirmed that traditional Chinese medicine(TCM)has significant advantages in the treatment of IBS-D since it can regulate the gut-brain axis via multiple pathways and targets to improve the gastrointestinal motility and strengthen immune defenses.However,there is a lack of systematic reviews on the regulation of the gut-brain axis by TCM in the treatment of IBS-D.Based on the review of IBS-D-related articles published in recent years,this paper systematically summarized the relationship between the gut-brain axis and IBS-D and the role of TCM in the treatment,providing new ideas for the treatment of IBS-D.

关 键 词：腹泻型肠易激综合征 肠-脑轴 中医药 研究进展 

分 类 号：R285[医药卫生—中药学] R289[医药卫生—中医学] R516.1