中药调控Wnt/β-catenin信号通路干预乳腺癌的研究进展  

Intervention of Breast Cancer by Regulating Wnt/β-catenin Signaling Pathway with Traditional Chinese Medicine:A Review

作　　者：凌璐 徐京育[2] 赵俊菲 刘松江[2] LING Lu;XU Jingyu;ZHAO Junfei;LIU Songjiang(The First Clinical Medical College of Heilongjiang University of Traditional Chinese Medicine(TCM),Harbin 150000,China;The First Affiliated Hospital of Heilongjiang University of TCM,Harbin 150000,China)

机构地区：[1]黑龙江中医药大学第一临床医学院,哈尔滨150000 [2]黑龙江中医药大学附属第一医院,哈尔滨150000

出　　处：《中国实验方剂学杂志》2025年第8期320-330,共11页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家中医药管理局标准化项目(GZY-FJS-2021-210);黑龙江省中医药科研项目(GY2022-05);高水平人才项目(2020GSP07);省级名中医专家传承工作室项目。

摘　　要：乳腺癌是全球常见的癌症之一,在中国发病率持续上升并趋于年轻化。经典Wnt/β-连环蛋白(Wnt/β-catenin)信号通路是乳腺癌治疗中的一个重要靶点,通过调控相关信号蛋白和基因的表达,在乳腺癌发展的整个过程扮演着关键角色。中药在恶性肿瘤治疗中有着深厚的历史和实践经验,现代科技的发展进一步凸显了中药多靶点、多成分的治疗优势。研究表明,中药通过调节Wnt/β-catenin信号通路,能有效减缓乳腺癌细胞的增殖和扩散,对乳腺癌的发展进程具有显著的抑制作用。基于此,该文整理和归纳了中药调控Wnt/β-catenin信号通路治疗乳腺癌的国内外相关研究,分析中药干预该信号通路抗乳腺癌的机制,总结出萜类(雷公藤甲素、穿心莲内酯等)、黄酮类(黄芩素、甜橙黄酮等)、糖类(当归多糖等)、酚类(姜黄素、虎杖苷等)及生物碱类(石蒜碱等)等44个不同类型的中药单体,3味中药(灵芝、藤梨根、牛樟芝),1组药对(鳖甲-莪术)和8个中药复方(复方土贝母、黄芪解毒汤、西黄丸、六味地黄丸、甲术汤、艾毒清方、四逆散、复方苦参注射液)。这些单味中药、中药单体和复方通过调节Wnt/β-catenin信号通路及其关键分子,可逆转上皮-间充质转化过程、降低干细胞活性、抑制癌细胞生长和转移,增强药物和放疗的敏感性,进而发挥抗乳腺癌的作用,为乳腺癌的药物研制和治疗方案提供新视角。Breast cancer is one of the most common cancers in the world,and its incidence rate is also rising in China and tends to happen in younger age groups.The classical Wnt/β-catenin signaling pathway is an important target in the treatment of breast cancer,playing a key role in the whole process of breast cancer development by regulating the expression of related signal proteins and genes.Traditional Chinese medicine has a profound history and practical experience in the treatment of malignant tumors,and the development of modern technology further highlights the therapeutic advantages of traditional Chinese medicine,which has multiple targets and components.Research shows that Chinese medicine can effectively slow down the proliferation of breast cancer cells by regulating the Wnt/β-catenin signaling pathway,and has a significant inhibitory effect on the development of breast cancer.Based on this,this paper summarized domestic and foreign relevant studies on the regulation of the Wnt/β-catenin signaling pathway with traditional Chinese medicine in the treatment of breast cancer,analyzed the mechanism of traditional Chinese medicine treating breast cancer by intervening in this signaling pathway,and summarized 44 different types of traditional Chinese medicine monomers,including terpenes(triptolide,andrographolide,etc.),flavonoids(scutellarin,sinensetin,etc.),polysaccharides(Angelica sinensis polysaccharides,etc.),phenols(curcumin,polydatin,etc.),and alkaloids(lycorine,etc.).In addition,there are 3 traditional Chinese medicines(Ganoderma lucidum,Radix actinidia chinensis,and Antrodia camphorata),1 group of medicine pairs(Trionycis Carapax-Zedoary Turmeric),and 8 traditional Chinese medicine formulas(Compound Tubeimu,Huangqi Jiedu Tang,Xihuang Wan,Liuwei Dihuang Wan,Jiazhu Tang,Aiduqing Fang,Sini San,and compound Kushen injection).By regulating the Wnt/β-catenin signaling pathway and its key molecules,these single herbs,monomers,and compound herbs can reverse the epithelial mesenchymal transformation process,reduc

关 键 词：乳腺癌 Wnt/β-连环蛋白(β-catenin)信号通路 中药 研究进展 作用机制 

分 类 号：R2-031[医药卫生—中西医结合] R273[医药卫生—中医学] R73