m^(6)A甲基化修饰在动物脂肪沉积中的调控作用研究进展  

Research Progress on the Regulatory Role of m^(6)A Methylation Modification in Animal Fat Deposition

作　　者：侯中一 徐茂胜 张正杰 孟聖博 李明[1] 李静 蔡含芳 Hou Zhongyi;Xu Maosheng;Zhang Zhengjie;Meng Shengbo;Li Ming;Li Jing;Cai Hanfang(Henan Agricultural University,Zhengzhou,450046,Henan;Henan Biyang County Modern Agricultural Industrial Park Service Center,Zhumadian,463700,Henan)

机构地区：[1]河南农业大学,河南郑州450046 [2]河南省泌阳县现代农业产业园服务中心,河南驻马店463700

出　　处：《中国畜禽种业》2025年第3期54-60,共7页The Chinese Livestock and Poultry Breeding

基　　金：河南省现代农业产业技术体系建设专项基金(G2013-08-G01);泌阳县国家现代农业产业园建设专项资金(NMAIP-BY-S01)。

摘　　要：N6-甲基腺苷(N6-methyladenosine,m^(6)A)是一种在RNA中普遍存在且动态可逆的化学修饰,通过在转录后水平调控RNA的剪切、翻译和稳定性,进而发挥调控细胞周期、细胞命运等重要的功能。近年来发现,m^(6)A修饰可以通过多种方式调节脂肪细胞的生长发育。该文对目前发现的与动物脂肪生成相关的m^(6)A修饰及其作用机制,包括甲基化酶(writers)、去甲基化酶(erasers)以及阅读蛋白(readers)在脂肪沉积中的作用进行综述,以期为深入研究动物脂肪沉积的分子机制提供理论参考。N6-methyladenosine(m^(6)A)is a ubiquitous and dynamically reversible chemical modification in RNA,which plays an important role in regulating the cell cycle,cell fate,and other important functions by modulating RNA shearing,translation,and stability at the post-transcriptional level.In recent years,it has been found that m^(6)A modification can regulate the growth and development of adipocytes in various ways.In this article,we review the m^(6)A modifications related to animal adipogenesis and their mechanisms of action,including the roles of methylation enzymes(writers),demethylation enzymes(erasers),and reading proteins(readers)in adipose deposition,with the aim of providing a theoretical basis for in-depth study of the molecular mechanisms of animal adipose deposition.

关 键 词：m^(6)A修饰 表观遗传调控 脂肪生成 脂肪沉积 

分 类 号：S828[农业科学—畜牧学]