肠道菌群与系统性红斑狼疮关系的研究进展  

Research progress of the relationship between gut microbiota and systemic lupus erythematosus

作　　者：郭林峰 张斌[1] 王宏智 杨明峰 Guo Lin-Feng;Zhang Bin;Wang Hong-Zhi;Yang Ming-Feng(Jiaxing University Master Degree Cultivation Base,Zhejiang Chinese Medical University,Hangzhou,Zhejiang 310053,China)

机构地区：[1]浙江中医药大学嘉兴大学联合培养基地,浙江杭州310053

出　　处：《解放军医学杂志》2025年第3期284-291,共8页Medical Journal of Chinese People's Liberation Army

基　　金：嘉兴市科技计划项目(2021AD30174)。

摘　　要：系统性红斑狼疮(SLE)是一种免疫系统异常激活后攻击自身组织导致的慢性弥漫性结缔组织病;其病程复杂,以血管炎为病理基础。近年来,关于SLE与肠道菌群关系的研究明显增多,但具体如何调节肠道菌群以治疗SLE尚未明确。研究发现,SLE患者的肠道菌群与健康人群在厚壁菌门、拟杆菌门、放线菌门、变形菌门等方面存在差异,且已在动物实验中得到验证。本文就SLE患者肠道菌群的变化及其与疾病发生发展的关系进行系统综述,以期为SLE的治疗提供新的思路。Systemic lupus erythematosus(SLE)is a chronic diffuse connective tissue disease characterized by abnormal activation of the immune system,which attacks the body's tissues.It has a complex course and its pathological basis is vasculitis.In recent years,research on the relationship between SLE and the gut microbiota has increased significantly,but how to regulate the gut microbiota for the treatment of SLE remains unclear.Studies have found that the intestinal microbiota of SLE patients differs from that of healthy people in terms of Firmicutes,Bacteroidetes,Actinomycetes,and Proteobacteria,etc.,and this has been verified in animal experiments.In this review,the changes of intestinal microbiota in SLE patients and their association with the pathogenesis and progression of the disease are systematically reviewed,aiming to provide new insights into the treatment of SLE.

关 键 词：系统性红斑狼疮 16S DNA 宏基因 肠道菌群 

分 类 号：R593.24[医药卫生—内科学]