脊髓损伤后微循环的调控机制及治疗策略  

Regulatory mechanisms and therapeutic strategies of microcirculation after spinal cord injury

作　　者：黄靖 任亚锋[2] 尚文雅 张芝兰 黄晓萌 李冰[2] Huang Jing;Ren Ya-Feng;Shang Wen-Ya;Zhang Zhi-Lan;Huang Xiao-Meng;Li Bing(Rehabilitation School of Henan University of Chinese Medicine,Zhengzhou,Henan 450046,China;Rehabilitation Center of the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou,Henan 450000,China)

机构地区：[1]河南中医药大学康复医学院,河南郑州450046 [2]河南中医药大学第一附属医院康复中心,河南郑州450000

出　　处：《解放军医学杂志》2025年第3期358-365,共8页Medical Journal of Chinese People's Liberation Army

基　　金：河南省中医药科学研究专项(2022JDZX015,2021JDZY022)。

摘　　要：脊髓损伤(SCI)是由各种因素导致的脊髓结构和功能破坏,进而引起的脊髓神经功能障碍。作为临床常见的中枢神经系统疾病,SCI的发生严重危害人们的生命健康,其病理机制十分复杂,涉及多种病理过程,其中考虑到原发性损伤的不可逆性,近些年靶向继发性损伤已逐渐成为临床治疗SCI的主要方向。研究表明,SCI后微循环中血脊髓屏障及微血管的破坏是导致继发性损伤的关键,而了解SCI后微循环的病理机制及相关靶向治疗策略可为SCI的临床治疗提供新思路。本文主要梳理了微循环在SCI中的作用,总结了微循环的主要调控因子,并归纳出针对微循环来治疗SCI的策略,以期为临床治疗SCI提供参考。Spinal cord injury(SCI)is a structural and functional disruption of the spinal cord caused by various factors,leading to neurological dysfunction.As a common central nervous system disorder in clinical practice,SCI poses significant risks to human life and health.Its pathological mechanism is exceedingly complex,involving multiple pathological processes.Given the irreversibility of primary injury,targeting secondary injury has gradually become the main direction for the clinical treatment of SCI in recent years.Recent studies have highlighted the crucial role of blood-spinal cord barrier damage and microvascular dysfunction in the progression of secondary injury following SCI.Therefore,investigating the pathological mechanisms of microcirculation and exploring targeted therapies could provide valuable insights for clinical SCI treatment.This paper aims to provide an objective review of the role of microcirculation in SCI,identify the critical regulators of microvascular function,and summarize strategies for treating SCI by targeting microcirculation.The findings of this study may offer novel references for the clinical management of SCI.

关 键 词：脊髓损伤 微循环 血脊髓屏障 调节因子 靶向治疗 

分 类 号：R651.2[医药卫生—外科学] R651.3[医药卫生—临床医学]