新生儿蜡样芽孢杆菌中枢神经系统感染1例  

Central nervous system infection caused by Bacillus cereus in a neonate

作　　者：俞蓉 王靓 容志惠[1] Yu Rong;Wang Jing;Rong Zhihui(Department of Neonatology,Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院新生儿科,武汉430030

出　　处：《中华围产医学杂志》2025年第3期253-257,共5页Chinese Journal of Perinatal Medicine

基　　金：武汉市知识创新专项(2023020201010158)。

摘　　要：本文报道1例蜡样芽孢杆菌中枢神经系统感染新生儿。患儿系出生胎龄33周+1早产儿,生后转孕母分娩医院儿科,因反复发热于2022年10月5日(38日龄)转入华中科技大学同济医学院附属同济医院。患儿生后多次脑脊液及头颅MRI检查均提示化脓性脑膜炎合并脑脓肿,但多次血培养及脑脊液培养均阴性。38日龄时脑脊液病原微生物宏基因组二代测序示蜡样芽孢杆菌群,予万古霉素、后续序贯利奈唑胺抗感染治疗,病情好转,67日龄出院。98日龄随访,头颅MRI较前好转,症状缓解。2岁时电话随访,患儿生长发育未见异常。This paper reported a central nervous system infection caused by Bacillus cereus in a neonate.The patient was born prematurely at 33 weeks of gestation and 1 day.He was transferred to Tongji Hospital affiliated to Tongji Medical College,Huazhong University of Science and Technology,on October 5,2022(day 38 of life),due to recurrent fever.Multiple cerebrospinal fluid and head MRI examinations indicated purulent meningitis with abscesses formation,though repeated blood and cerebrospinal fluid cultures were negative.At 38 days of life,metagenomic next-generation sequencing of the cerebrospinal fluid pathogens revealed the presence of the Bacillus cereus group.The patient was treated with vancomycin followed by sequential linezolid for anti-infective therapy,leading to significant improvement.The patient was discharged on day 67 of life.Follow-up at 98 days of life showed improved head MRI findings and symptom resolution.At 2 years of age,telephone follow-up indicated normal growth and development with no abnormalities.

关 键 词：蜡样芽孢杆菌 中枢神经系统感染 早产儿 母乳 

分 类 号：R722.1[医药卫生—儿科]