基于纳米生物材料技术的脓毒症治疗新策略  

New strategy for sepsis treatment based on nanobiomaterial technology

作　　者：姚咏明[1] 张卉 董宁[1] Yao Yongming;Zhang Hui;Dong Ning(Medical Innovation Research Department and the Fourth Medical Center of PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院医学创新研究部、第四医学中心,北京100853

出　　处：《中华烧伤与创面修复杂志》2025年第3期206-211,共6页Chinese Journal of Burns And Wounds

基　　金：国家重点研发计划(2022YFA1104604);国家自然科学基金重点项目(82241062);国家自然科学基金面上项目(82472194)。

摘　　要：脓毒症的病理生理机制复杂,主要涉及过度炎症反应和免疫功能紊乱。纳米生物材料技术的发展给脓毒症治疗带来了全新选择。该文从抗菌、抗炎、靶向调控免疫细胞功能、多靶向联合调控等方面论述了纳米生物材料在脓毒症治疗中的应用现状和潜力,为未来开发基于纳米生物材料的脓毒症治疗策略开辟新方向。The pathophysiological mechanisms underlying sepsis is complex,mainly involving excessive inflammatory response and immune dysfunction.The development of nanobiomaterial technology has brought brand-new options for the treatment of sepsis.In the current paper,we discuss the current application status and potential of nanobiomaterials in treatment of sepsis from aspects of antibacterial,anti-inflammatory,targeted regulation of immune cell function,and multi-target combined regulation,pointing out new direction for the future development of therapeutic strategies for sepsis based on nanobiomaterials.

关 键 词：脓毒症 生物相容性材料 纳米颗粒 药物递送系统 

分 类 号：R459.7[医药卫生—急诊医学]