水凝胶促进创面血管化的研究进展  

Research advances on hydrogels for promoting wound vascularization

作　　者：石傲 王运帷 康宇晨 王刚[1] 刘毅[1] Shi Ao;Wang Yunwei;Kang Yuchen;Wang Gang;Liu Yi(Department of Burns and Plastic Surgery&Wound Repair Surgery,Lanzhou University Second Hospital,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院烧伤整形与创面修复外科,兰州730030

出　　处：《中华烧伤与创面修复杂志》2025年第3期295-300,共6页Chinese Journal of Burns And Wounds

基　　金：国家自然科学基金地区科学基金项目(82360444);甘肃省高校产业支撑项目(2023CYZC-02)。

摘　　要：高糖诱导的血管内皮细胞损伤是糖尿病创面难以愈合的主要病理因素,创面有效血管化一直是组织工程研究的核心挑战。基于水凝胶的可注射技术与三维生物打印技术,通过生物材料与先进制造工艺的协同创新,能够精确构建仿生组织结构,为功能性器官替代奠定基础。该综述重点讨论了可注射水凝胶与三维生物打印水凝胶在组织工程血管化中的协同策略、目前亟待发展的术中生物打印及其协同血管化策略的临床转化,有望为糖尿病创面修复提供新的策略。High glucose-induced vascular endothelial cell injury serves as a primary pathological factor contributing to delayed healing of diabetic wounds.Effective wound vascularization remains a core challenge in tissue engineering research.Hydrogel-based injectable technology and three-dimensional(3D)bioprinting technology,through synergistic innovation of biomaterials and advanced manufacturing processes,enable precise construction of bionic tissue structures,laying the foundation for functional organ replacement.This review focuses on discussing the synergistic strategies of injectable hydrogels and 3D bioprinted hydrogels in tissue engineering vascularization,as well as the clinical translation of intraoperative bioprinting and its synergistic vascularization strategies,which is currently in urgent need of development.These advancements are expected to provide novel strategies for the repair of diabetic wounds.

关 键 词：生物相容性材料 新生血管化 生理性 伤口愈合 水凝胶 生物打印 

分 类 号：R318.08[医药卫生—生物医学工程]